RNA 5‐Methylcytosine Modification Regulates Vegetative Development Associated with H3K27 Trimethylation in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204885
Abstract: Methylating RNA post‐transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals. However, it is… read more here.
Keywords: modification; trimethylation; rna; m5c ... See more keywords
H3K4 trimethylation dynamics impact diverse developmental and environmental responses in plants
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DOI: 10.1007/s00425-020-03520-0
Abstract: Main conclusion The H3K4me3 histone mark in plants functions in the regulation of gene expression and transcriptional memory, and influences numerous developmental processes and stress responses. Abstract Plants execute developmental programs and respond to changing… read more here.
Keywords: trimethylation; gene expression; h3k4me3; developmental environmental ... See more keywords
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes
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DOI: 10.1038/s41560-018-0079-2
Abstract: Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active promoters yet paradoxically occurs at untranscribed domains. Research to delineate the mechanisms of targeting H3K4 methyltransferases is ongoing. The oocyte provides an attractive… read more here.
Keywords: transcription independent; h3k4 trimethylation; trimethylation; independent h3k4 ... See more keywords
Modification of histone 3 lysine 27 (H3K27) trimethylation in EZH2 and JMJD3 deficient T cells attenuates atherosclerosis through polarization towards anti-inflammatory phenotypes
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DOI: 10.1093/ehjci/ehaa946.3829
Abstract: The trimethylation status of Histone 3 Lysine 27 (H3K27), which is regulated by the methylating enzyme Enchancer of zeste homolog 2 (EZH2) and the demethylating enzyme Jumonji domain containing 3 (JMJD3), is a critical epigenetic… read more here.
Keywords: trimethylation; ezh2 jmjd3; polarization; mice ... See more keywords
Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection.
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DOI: 10.1126/sciadv.aba0647
Abstract: While N 6-methyladenosine (m6A) is the most prevalent modification of eukaryotic messenger RNA (mRNA) involved in various cellular responses, its role in modulating bacteria-induced inflammatory response remains elusive. Here, we showed that loss of the… read more here.
Keywords: trimethylation; bacterial infection; h3k27me3; m6a ... See more keywords
Antisense oligonucleotide therapy for H3.3K27M diffuse midline glioma
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.add8280
Abstract: Diffuse midline gliomas (DMGs) are pediatric high-grade brain tumors in the thalamus, midbrain, or pons; the latter subgroup are termed diffuse intrinsic pontine gliomas (DIPG). The brain stem location of these tumors limits the clinical… read more here.
Keywords: diffuse midline; trimethylation; therapy; dipg ... See more keywords
Hypoxia inducible factor-1α cooperates with histone Lys methylation to predict prognosis in esophageal squamous cell carcinoma.
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DOI: 10.2217/bmm-2020-0256
Abstract: Aim: To investigate hypoxia inducible factor-1α (HIF-1α) and histone methylation markers as potential indicators of prognosis in esophageal squamous cell carcinoma (ESCC). Patients & methods: The prognostic value of HIF-1α and histone methylation markers levels was analyzed using… read more here.
Keywords: methylation; trimethylation; inducible factor; escc ... See more keywords
Lack of the COMPASS Component Ccl1 Reduces H3K4 Trimethylation Levels and Affects Transcription of Secondary Metabolite Genes in Two Plant–Pathogenic Fusarium Species
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DOI: 10.3389/fmicb.2016.02144
Abstract: In the two fungal pathogens Fusarium fujikuroi and Fusarium graminearum, secondary metabolites (SMs) are fitness and virulence factors and there is compelling evidence that the coordination of SM gene expression is under epigenetic control. Here,… read more here.
Keywords: trimethylation; fusarium; plant; ccl1 ... See more keywords