EZH2 inhibitors abrogate upregulation of trimethylation of H3K27 by CDK9 inhibitors and potentiate its activity against diffuse large B-cell lymphoma
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DOI: 10.3324/haematol.2019.222935
Abstract: Aberrant expression of CDK9/cyclin T1 has been found in diffuse large B-cell lymphoma (DLBCL), and suggests that CDK9 is a potential therapeutic target for DLBCL. Here, we firstly demonstrated that CDKI-73, a novel cyclin-dependent kinases… read more here.
Keywords: cdk9 inhibitors; ezh2 inhibitors; cdk9; trimethylation h3k27 ... See more keywords