Measuring Dynamic Behavior of Trinucleotide Repeat Tracts In Vivo in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7306-4_30
Abstract: Trinucleotide repeat (TNR) tracts are inherently unstable during DNA replication, leading to repeat expansions and/or contractions. Expanded tracts are the cause of over 40 neurodegenerative and neuromuscular diseases. In this chapter, we focus on the… read more here.
Keywords: saccharomyces cerevisiae; repeat; trinucleotide repeat; behavior trinucleotide ... See more keywords
TCF4-mediated Fuchs endothelial corneal dystrophy: Insights into a common trinucleotide repeat-associated disease
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2020.100883
Abstract: Fuchs endothelial corneal dystrophy (FECD) is a common cause for heritable visual loss in the elderly. Since the first description of an association between FECD and common polymorphisms situated within the transcription factor 4 (TCF4)… read more here.
Keywords: expansion; fuchs endothelial; repeat; disease ... See more keywords
Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.07.018
Abstract: GW182 (also known asTNRC6) family members are critically involved in the final effector phase of miRNA-mediated mRNA repression. The three mammalian paralogs, TNRC6a, b and c, are thought to be redundant based on Argonaute (Ago)… read more here.
Keywords: tgf family; tnrc6c mutants; trinucleotide repeat; tnrc6c ... See more keywords
Versatile Target-Guided Screen for Discovering Bidirectional Transcription Inhibitors of a Trinucleotide Repeat Disease.
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DOI: 10.1021/acsmedchemlett.1c00064
Abstract: Myotonic dystrophy type 1 originates from d(CTG·CAG) repeats that undergo aberrant expansion during normal processing because the d(CTG) repeat forms stable hairpin structures. Bidirectional transcription of d(CTG·CAG) yields two RNA transcripts that undergo repeat-associated non-ATG… read more here.
Keywords: transcription; bidirectional transcription; target guided; repeat ... See more keywords
Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy.
Sign Up to like & getrecommendations! Published in 2019 at "Cornea"
DOI: 10.1097/ico.0000000000001952
Abstract: PURPOSE To investigate single nucleotide polymorphisms (SNPs) and trinucleotide repeat (TNR) expansion in the transcription factor 4 (TCF4) gene in a large cohort of German patients with Fuchs endothelial corneal dystrophy (FECD). METHODS Genomic DNA… read more here.
Keywords: rs613872; fecd; corneal; trinucleotide repeat ... See more keywords
Genomic relationships among sixteen species of Avena based on (ACT)6 trinucleotide repeat FISH.
Sign Up to like & getrecommendations! Published in 2018 at "Genome"
DOI: 10.1139/gen-2017-0132
Abstract: Knowledge of the locations of repeat elements could be very important in the assembly of genome sequences and their assignment to physical chromosomes. Genomic and species relationships among 16 species were investigated using fluorescence in… read more here.
Keywords: relationships among; act; genomic relationships; trinucleotide repeat ... See more keywords