Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.03.031
Abstract: Background Huntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD. We previously reported that CAG… read more here.
Keywords: intelligence; trinucleotide repeats; repeat; effect ... See more keywords
Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions
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DOI: 10.1371/journal.pgen.1008924
Abstract: Microsatellites are short tandem repeats, ubiquitous in all eukaryotes and represent ~2% of the human genome. Among them, trinucleotide repeats are responsible for more than two dozen neurological and developmental disorders. Targeting microsatellites with dedicated… read more here.
Keywords: trinucleotide repeats; strand; strand break; double strand ... See more keywords
Bioinformatics Analysis of the Interaction of miRNAs and piRNAs with Human mRNA Genes Having di- and Trinucleotide Repeats
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DOI: 10.3390/genes13050800
Abstract: The variability of nucleotide repeats is considered one of the causes of diseases, but their biological function is not understood. In recent years, the interaction of miRNAs and piRNAs with the mRNAs of genes responsible… read more here.
Keywords: trinucleotide repeats; mirnas pirnas; interaction mirnas; pirna binding ... See more keywords