A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency
Sign Up to like & getrecommendations! Published in 2021 at "SLAS Discovery"
DOI: 10.1177/24725552211018198
Abstract: Triose phosphate isomerase deficiency (TPI Df) is an untreatable, childhood-onset glycolytic enzymopathy. Patients typically present with frequent infections, anemia, and muscle weakness that quickly progresses with severe neuromusclar dysfunction requiring aided mobility and often respiratory… read more here.
Keywords: triose phosphate; phosphate isomerase; tpi; tpi treatments ... See more keywords
[Triose phosphate isomerase deficiency: a rare erythrocyte enzymopathy with a poor prognosis].
Sign Up to like & getrecommendations! Published in 2023 at "Annales de biologie clinique"
DOI: 10.1684/abc.2023.1789
Abstract: Triose phosphate isomerase (TPI) is a crucial enzyme for glycolysis. TPI deficiency is an autosomal recessive metabolic disease described in 1965, which remains exceptional by its rarity (less than 100 cases described worldwide), but by… read more here.
Keywords: isomerase deficiency; phosphate isomerase; triose phosphate;
Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210913090928
Abstract: BACKGROUND Parasitic diseases caused by protozoa such as Chagas disease, leishmaniasis, malaria, African trypanosomiasis, amebiasis, trichomoniasis, and giardiasis are considered serious public health problems in developing countries. Drug-resistance among parasites justifies the search for new… read more here.
Keywords: triose phosphate; antiprotozoal agents; inhibitors antiprotozoal; tim ... See more keywords
Density Functional Theory Calculations and Molecular Docking Analyses of Flavonoids for Their Possible Application against the Acetylcholinesterase and Triose-Phosphate Isomerase Proteins of Rhipicephalus microplus
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083606
Abstract: Ticks and tick-borne diseases constitute a substantial hazard to the livestock industry. The rising costs and lack of availability of synthetic chemical acaricides for farmers with limited resources, tick resistance to current acaricides, and residual… read more here.
Keywords: molecular docking; triose phosphate; rhipicephalus microplus; proteins rhipicephalus ... See more keywords