Highly Similar Sequence and Structure Yet Different Biophysical Behavior: A Computational Study of Two Triosephosphate Isomerases
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DOI: 10.1021/acs.jcim.1c01501
Abstract: Homodimeric triosephosphate isomerases (TIMs) from Trypanosoma cruzi (TcTIM) and Trypanosoma brucei (TbTIM) have markedly similar amino-acid sequences and three-dimensional structures. However, several of their biophysical parameters, such as their susceptibility to sulfhydryl agents and their… read more here.
Keywords: highly similar; sequence structure; triosephosphate isomerases; triosephosphate ... See more keywords