Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13396
Abstract: Recruitment of plasminogen is an important infection strategy of the human pathogen Streptococcus pneumoniae to invade host tissues. In Streptococcus aureus, triosephosphate isomerase (TPI) has been reported to bind plasminogen. In this study, the TPI of S. pneumoniae… read more here.
Keywords: autolysis binds; triosephosphate isomerase; pneumoniae; plasminogen ... See more keywords
Synergistic effect of compounds directed to triosephosphate isomerase, a combination to develop drug against trichomoniasis
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200046
Abstract: The development of new drugs is continuous in the world; currently, saving resources (both economic ones and time) and preventing secondary effects have become a necessity for drug developers. Trichomoniasis is the most common nonviral… read more here.
Keywords: triosephosphate isomerase; effect; combination; synergistic effect ... See more keywords
Structure and conformational stability of the triosephosphate isomerase from Zea mays. Comparison with the chemical unfolding pathways of other eukaryotic TIMs.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.09.022
Abstract: We studied the structure, function and thermodynamic properties for the unfolding of the Triosephosphate isomerase (TIM) from Zea mays (ZmTIM). ZmTIM shows a catalytic efficiency close to the diffusion limit. Native ZmTIM is a dimer… read more here.
Keywords: zmtim; triosephosphate isomerase; structure; eukaryotic tims ... See more keywords
Evaluating the catalytic importance of a conserved Glu97 residue in triosephosphate isomerase.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.076
Abstract: Investigating enzyme activity is central to our understanding of biological function, and the design of biocatalysts continues to find applications in synthesis. While a role for active site residues can be proposed based on structure… read more here.
Keywords: triosephosphate isomerase; active site; site; tim ... See more keywords
Triosephosphate Isomerase and Filamin C Share Common Epitopes as Novel Allergens of Procambarus clarkii.
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DOI: 10.1021/acs.jafc.6b04587
Abstract: Triosephosphate isomerase (TIM) is a key enzyme in glycolysis and has been identified as an allergen in saltwater products. In this study, TIM with a molecular mass of 28 kDa was purified from the freshwater… read more here.
Keywords: triosephosphate isomerase; common epitopes; isomerase filamin; procambarus clarkii ... See more keywords
Crystal structure analysis and conformational epitope mutation of triosephosphate isomerase, a mud crab allergen.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b05279
Abstract: The triosephosphate isomerase (TIM), Scy p 8, is a crab allergen and shows cross-reactivity in shellfish. Here, recombinant Scy p 8 was expressed and its crystal structure was determined at a resolution of 1.8 Å.… read more here.
Keywords: crystal structure; crab allergen; triosephosphate isomerase; structure ... See more keywords
Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphate Isomerase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b08713
Abstract: We report results of detailed empirical valence bond simulations that model the effect of several amino acid substitutions on the thermodynamic (ΔG°) and kinetic activation (ΔG⧧) barriers to deprotonation of dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde… read more here.
Keywords: triosephosphate isomerase; side chains; deprotonation; wild type ... See more keywords
Child Neurology: Triosephosphate isomerase deficiency
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DOI: 10.1212/wnl.0000000000010745
Abstract: Triosephosphate isomerase (TPI) deficiency is a rare autosomal recessive disease of infancy and childhood classified as a glycolytic enzymopathy. Clinical features include hemolytic anemia, progressive neuromuscular dysfunction, and increased susceptibility to infection with specific pathogenic… read more here.
Keywords: triosephosphate isomerase; deficiency; child neurology; neurology triosephosphate ... See more keywords
Structural Analysis of an Epitope Candidate of Triosephosphate Isomerase in Opisthorchis viverrini.
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DOI: 10.2210/pdb5zga/pdb
Abstract: Opisthorchis viverrini, a parasitic trematode, was recategorized as a group 1 biological carcinogen because it causes opisthorchiasis, which may result in cholangiocarcinoma. A new strategy for controlling opisthorchiasis is needed because of issues such as… read more here.
Keywords: opisthorchis viverrini; epitope; triosephosphate isomerase;