Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22319-5
Abstract: The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in… read more here.
Keywords: fbw7; tumour suppressor; proteasomal degradation; suppressor fbw7 ... See more keywords
E3 Ubiquitin Ligase TRIP12 Controls Exit from Mitosis via Positive Regulation of MCL-1 in Response to Taxol
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DOI: 10.3390/cancers15020505
Abstract: Simple Summary Taxol is a chemotherapy drug used in treatment of multiple cancers. Taxol works by blocking an essential process of cell division called mitosis. Although, Taxol treatment shows promise in fight against cancer, many… read more here.
Keywords: cell; trip12; taxol; ubiquitin ligase ... See more keywords
E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions
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DOI: 10.3390/ijms21228515
Abstract: The Thyroid hormone Receptor Interacting Protein 12 (TRIP12) protein belongs to the 28-member Homologous to the E6-AP C-Terminus (HECT) E3 ubiquitin ligase family. First described as an interactor of the thyroid hormone receptor, TRIP12’s biological… read more here.
Keywords: trip12 regulation; ubiquitin ligase; trip12; ligase trip12 ... See more keywords