TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.01.023
Abstract: Targeted protein degradation is an emerging therapeutic paradigm. Small-molecule degraders such as proteolysis-targeting chimeras (PROTACs) induce the degradation of neo-substrates by hijacking E3 ubiquitin ligases. Although ubiquitylation of endogenous substrates has been extensively studied, the… read more here.
Keywords: k29 k48; degradation; k48 branched; branched ubiquitin ... See more keywords