DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13201
Abstract: Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is upregulated in various human cancers, including colorectal cancer (CRC). This study focused on the inhibition of TRIP13‐induced CRC progression and signalling by DCZ0415,… read more here.
Keywords: wnt catenin; trip13; dcz0415; crc ... See more keywords
TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN4
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23303
Abstract: Increasing evidence has indicated that thyroid hormone receptor interacting protein 13 (TRIP13) exerts a cancer‐promoting role in a broad spectrum of cancers. However, the detailed relevance and function of TRIP13 in cervical cancer remain undefined.… read more here.
Keywords: catenin signaling; cervical cancer; trip13; cancer ... See more keywords
Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0281-1
Abstract: The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an inhibitor of the anaphase-promoting complex (APC/C, also known as the cyclosome)1,2.… read more here.
Keywords: p31comet; mcc; atpase trip13; trip13 ... See more keywords
TRIP13/FLNA Complex Promotes Tumor Progression and Is Associated with Unfavorable Outcomes in Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/1419179
Abstract: Cutaneous melanoma is a high-grade malignant tumor originating from skin melanocytes with high risk of recurrence and metastasis. Further study on the mechanism of melanoma development is urgently needed. Here, we performed a bioinformatic analysis… read more here.
Keywords: melanoma; trip13; flna; melanoma cells ... See more keywords
TRIP13 Modulates Protein Deubiquitination to Promote Myeloma Progression
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-123818
Abstract: Thyroid Hormone Receptor 13 (TRIP13) is an exciting emerging epitope in numerous cancers and is related to genomic integrity. In multiple myeloma (MM), TRIP13 is the third most upregulated gene in the 70-gene high-risk signature… read more here.
Keywords: myc mice; trip13; progression; trip13 myc ... See more keywords
Loss of thyroid hormone receptor interactor 13 inhibits cell proliferation and survival in human chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16038
Abstract: Background The genetic regulation of apoptosis and cell proliferation plays a role in the growth of chronic lymphocytic leukemia (CLL), the most common form of leukemia in the Western hemisphere. Although thyroid hormone receptor interactors… read more here.
Keywords: cll; cell proliferation; proliferation; trip13 ... See more keywords
TRIP13 promotes proliferation and invasion of epithelial ovarian cancer cells through Notch signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201901_16864
Abstract: OBJECTIVE Growing evidence supports the involvement of Thyroid hormone Receptor Interactor 13 (TRIP13) in the progression and metastasis of multiple cancers. However, the roles of TRIP13 in epithelial ovarian cancer (EOC) remains unknown. The present… read more here.
Keywords: cell; invasion; eoc; signaling pathway ... See more keywords
Clinical Significance and Systematic Expression Analysis of the Thyroid Receptor Interacting Protein 13 (TRIP13) as Human Gliomas Biomarker
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13102338
Abstract: Simple Summary High expression of TRIP13 is associated with IDH-wild type gliomas. Patients with elevated TRIP13 levels are indicative of the poor survival outcome. The study aimed to provide comprehensive information about the oncogenic potential… read more here.
Keywords: protein; gliomas; trip13; expression ... See more keywords
Upregulation of thyroid hormone receptor interactor 13 is associated with human hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6767
Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. Thyroid hormone receptor interactor 13 (TRIP13) has been reported to promote nonhomologous end joining (NHEJ). However, the role of TRIP13 in the molecular pathogenesis of HCC remains… read more here.
Keywords: hepatocellular carcinoma; hcc; trip13 expression; trip13 ... See more keywords
TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Oncology Reports"
DOI: 10.3892/or.2023.8521
Abstract: Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancers and remains the most common cause of cancer-related death. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) have been used as first-line… read more here.
Keywords: cell; trip13; gefitinib resistance; resistance ... See more keywords