Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Microbiology"
DOI: 10.1007/s12275-019-8520-1
Abstract: Tripartite efflux pumps and the type I secretion system of Gram-negative bacteria are large protein complexes that span the entire cell envelope. These complexes expel antibiotics and other toxic substances or transport protein toxins from… read more here.
Keywords: secretion system; pumps type; type secretion; efflux pumps ... See more keywords
Sequence- and structure-based computational analyses of Gram-negative tripartite efflux pumps in the context of bacterial membranes.
Sign Up to like & getrecommendations! Published in 2018 at "Research in microbiology"
DOI: 10.1016/j.resmic.2018.01.002
Abstract: Gram-negative multidrug resistance currently presents a serious threat to public health with infections effectively rendered untreatable. Multiple molecular mechanisms exist that cause antibiotic resistance and in addition, the last three decades have seen slowing rates… read more here.
Keywords: gram negative; negative tripartite; resistance; sequence structure ... See more keywords
Tripartite efflux pumps of the RND superfamily: what did we learn from computational studies?
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology"
DOI: 10.1099/mic.0.001307
Abstract: Bacterial resistance to antibiotics has been long recognized as a priority to address for human health. Among all micro-organisms, the so-called multi-drug resistant (MDR) bacteria, which are resistant to most, if not all drugs in… read more here.
Keywords: efflux pumps; tripartite efflux; mdr; pumps rnd ... See more keywords
A Model for Allosteric Communication in Drug Transport by the AcrAB-TolC Tripartite Efflux Pump
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DOI: 10.3390/antibiotics11010052
Abstract: RND family efflux pumps are complex macromolecular machines involved in multidrug resistance by extruding antibiotics from the cell. While structural studies and molecular dynamics simulations have provided insights into the architecture and conformational states of… read more here.
Keywords: state; tripartite efflux; transport; pump ... See more keywords
A Tripartite Efflux System Affects Flagellum Stability in Helicobacter pylori
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DOI: 10.3390/ijms231911609
Abstract: Helicobacter pylori uses a cluster of polar, sheathed flagella for swimming motility. A search for homologs of H. pylori proteins that were conserved in Helicobacter species that possess flagellar sheaths but were underrepresented in Helicobacter… read more here.
Keywords: tripartite efflux; flagellum stability; helicobacter pylori; efflux system ... See more keywords