The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28971
Abstract: Tripartite motif 8 (TRIM8), an E3 ligase ubiquitously expressed in various cells, is closely involved in innate immunity. However, its role in nonalcoholic steatohepatitis is largely unknown. Here, we report evidence that TRIM8 is a… read more here.
Keywords: trim8; tripartite motif; steatohepatitis; insulin resistance ... See more keywords
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-021-03518-4
Abstract: Tripartite motif-containing protein (TRIM16) is a newly identified oxidative-stress-responsive protein. Oxidative stress is a hallmark of myocardial ischemia/reperfusion (I/R) injury and contributes to the cardiac injury. To date, whether TRIM16 plays a role in mediating… read more here.
Keywords: protein; myocardial injury; tripartite motif; motif containing ... See more keywords
Cloning, analysis, and anti–duck Tembusu virus innate immune response of Cherry Valley duck tripartite motif-containing 32
Sign Up to like & getrecommendations! Published in 2021 at "Poultry Science"
DOI: 10.1016/j.psj.2021.101048
Abstract: Tripartite motif-containing 32 (TRIM32) is an E3 ubiquitin ligase with multiple functions. In this study, we amplified TRIM32 gene from the Cherry Valley duck, and its cDNA sequence contained an open reading frame of 1,950… read more here.
Keywords: response; duck; tripartite motif; cherry valley ... See more keywords
Tripartite motif family proteins in inflammatory bowel disease: Mechanisms and potential for interventions
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13222
Abstract: Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal inflammatory disease that poses a heavy burden to the global healthcare system. However, the current paucity of mechanistic understanding of IBD pathogenesis hampers the development of… read more here.
Keywords: family; disease; inflammatory bowel; tripartite motif ... See more keywords
Tripartite motif‐containing proteins precisely and positively affect host antiviral immune response
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12669
Abstract: The tripartite motif‐containing proteins (TRIMs) comprise a large family of proteins with over 70 members in humans. Recent studies have shown that TRIMs play unexpected roles in the antiviral immune responses to infections by HIV,… read more here.
Keywords: containing proteins; tripartite motif; motif containing; host ... See more keywords
Tripartite motif-containing protein 21 is involved in IFN-γ-induced suppression of hepatitis B virus by regulating hepatocyte nuclear factors
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Virology"
DOI: 10.1128/jvi.00468-24
Abstract: ABSTRACT The antiviral role of the tripartite motif-containing (TRIM) protein family , a member of the E3-ubiquitin ligase family, has recently been actively studied. Hepatitis B virus (HBV) infection is a major contributor to liver… read more here.
Keywords: hbv; hepatitis virus; tripartite motif; motif containing ... See more keywords
MyoTRIM, an engineered tripartite motif (TRIM) protein, recapitulates canonical phosphatidylserine binding and enhances cell membrane resealing capacity
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1462
Abstract: Duchenne Muscular Dystrophy (DMD) is the most prevalent hereditary neuromuscular disease and involves progressive muscle degeneration that contributes to early death. DMD is caused by mutations in the dystrophin gene, which eliminates its expression and… read more here.
Keywords: membrane resealing; physiology; tripartite motif; mg53 ... See more keywords
Tripartite motif 47 promotes the development of thyroid carcinoma through ADAR ubiquitination
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Medicine"
DOI: 10.1186/s10020-025-01298-z
Abstract: Tripartite motif 47 (TRIM47) plays a vital role in the carcinogenesis and drug resistance of various cancers, whereas the function of TRIM47 in thyroid carcinoma (TC) remains unclear. Human study and animal experiments were performed.… read more here.
Keywords: tripartite motif; trim47; adar; thyroid carcinoma ... See more keywords
MON-310 Oncogenic Roles of Tripartite Motif 25 in Endometrial Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-310
Abstract: Abstract The tripartite motif (TRIM) family proteins are known for their structure typically composed of integrated three components of RING, B-box and coiled-coil domains. Some of the TRIM proteins have been paid attention as they… read more here.
Keywords: trim25; mon 310; cancer cells; cancer ... See more keywords
E3 ubiquitin ligase tripartite motif-containing 71 promotes the proliferation of non-small cell lung cancer through the inhibitor of kappaB-α/nuclear factor kappaB pathway
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.19075
Abstract: Tripartite motif-containing (TRIM) 71 belongs to the TRIM protein family. Many studies have shown that TRIM71 plays conserved roles in stem cell proliferation, differentiation, and embryonic development; however, the relationship between TRIM71 and tumorigenesis is… read more here.
Keywords: proliferation; tripartite motif; motif containing; non small ... See more keywords
Human tripartite motif protein 52 is required for cell context-dependent proliferation
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24422
Abstract: Tripartite motif (TRIM) proteins have been shown to play important roles in cancer development and progression by modulating cell proliferation or resistance from cell death during non-homeostatic stress conditions found in tumor micro-environments. In this… read more here.
Keywords: human tripartite; proliferation; tripartite motif; trim52 ... See more keywords