Ultrastructural and functional changes at the tripartite synapse during epileptogenesis in a model of temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113196
Abstract: The persistent unresponsiveness of many of the acquired epilepsies to traditional antiseizure medications has motivated the search for prophylactic drug therapies that could reduce the incidence of epilepsy in this at risk population. These studies… read more here.
Keywords: epilepsy; epileptogenesis; period; ultrastructural functional ... See more keywords
Interplay between biochemical processes and network properties generates neuronal up and down states at the tripartite synapse.
Sign Up to like & getrecommendations! Published in 2023 at "Physical review. E"
DOI: 10.1103/physreve.107.024415
Abstract: Neuronal up and down states have long been known to exist both in vitro and in vivo. A variety of functions and mechanisms have been proposed for their generation, but there has not been a… read more here.
Keywords: network; level; tripartite synapse; states tripartite ... See more keywords
Beyond NMDA Receptors: Homeostasis at the Glutamate Tripartite Synapse and Its Contributions to Cognitive Dysfunction in Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158617
Abstract: Cognitive deficits are core symptoms of schizophrenia but remain poorly addressed by dopamine-based antipsychotic medications. Glutamate abnormalities are implicated in schizophrenia-related cognitive deficits. While the role of the NMDA receptor has been extensively studied, less… read more here.
Keywords: tripartite synapse; cognitive dysfunction; synapse; homeostasis glutamate ... See more keywords