Adenosine triphosphate enhances osteoblast differentiation of rat dental pulp stem cells via the PLC–IP3 pathway and intracellular Ca 2+ signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29091
Abstract: Intracellular Ca2+ signals are essential for stem cell function and play a significant role in the differentiation process. Dental pulp stem cells (DPSCs) are a potential source of stem cells; however, the mechanisms controlling cell… read more here.
Keywords: triphosphate; differentiation; dental pulp; pulp stem ... See more keywords
A fluorescence aptasensor based on two-dimensional sheet metal-organic frameworks for monitoring adenosine triphosphate.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.10.028
Abstract: In the present study, a facile fluorescence aptasensor based on two-dimensional sheet metal-organic frameworks of N,N-bis(2-hydroxyethyl)dithiooxamidato copper(II) (H2dtoaCu) was developed for the sensitive detection of adenosine triphosphate (ATP). The sensing mechanism was based on the… read more here.
Keywords: fluorescence; aptasensor; aptasensor based; triphosphate ... See more keywords
Allosteric regulation of arylamine N‐acetyltransferase 1 by adenosine triphosphate
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.013
Abstract: &NA; In the present study, a screen of adenosine analogs as potential modulators of arylamine‐N‐acetyltransferase 1 activity identified ATP as an inhibitor within its range of physiological concentrations. Kinetically, ATP was a non‐competitive inhibitor with… read more here.
Keywords: allosteric regulation; acetyltransferase; lysine 100; triphosphate ... See more keywords
Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.7b00173
Abstract: Members of the nucleoside analogue class of cancer therapeutics compete with canonical nucleotides to disrupt numerous cellular processes, including nucleotide homeostasis, DNA and RNA synthesis, and nucleotide metabolism. Nucleoside analogues are triphosphorylated and subsequently inserted… read more here.
Keywords: structures dna; dna; dna polymerase; modified nucleotides ... See more keywords
Triphosphate Prodrugs of the Anti-HIV-Active Compound 3'-Deoxy-3'-fluorothymidine (FLT).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00665
Abstract: 3'-Fluoro-3'-deoxythymidine (FLT) was identified as one of the most potent inhibitors of human immunodeficiency virus (HIV) replication. However, FLT also showed severe toxicity so that it was abundant as a potential chemotherapeutic agent. Here, we… read more here.
Keywords: triphosphate prodrugs; flt; hiv active; prodrugs anti ... See more keywords
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-00537-9
Abstract: Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent drug and its active metabolites have been poorly characterized to… read more here.
Keywords: rdv; nucleotide monophosphate; triphosphate; remdesivir ... See more keywords
Naphthalimide-linked bispyridinium clefts in selective aqueous sensing of triphosphate and triphosphate-based biomolecules
Sign Up to like & getrecommendations! Published in 2019 at "Analytical Methods"
DOI: 10.1039/c9ay01588d
Abstract: Naphthalimide-based charged chemosensors 1 and 2 selectively bind P3O105− and ATP in aqueous CH3CN over a series of anions including ADP and AMP by exhibiting marked quenching of emission. Sensor 1 shows greater sensitivity than… read more here.
Keywords: clefts selective; selective aqueous; bispyridinium clefts; triphosphate ... See more keywords
Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis
Sign Up to like & getrecommendations! Published in 2017 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000002052
Abstract: Objective: Sepsis remains an unresolved clinical problem. Therapeutic strategies focusing on inhibition of neutrophils (polymorphonuclear neutrophils) have failed, which indicates that a more detailed understanding of the underlying pathophysiology of sepsis is required. Polymorphonuclear neutrophil… read more here.
Keywords: sepsis; systemic adenosine; polymorphonuclear neutrophil; adenosine triphosphate ... See more keywords
Novel mechanism of impaired metabolism‐secretion coupling in β‐cells: Loss of cytosolic adenosine triphosphate by leakage
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13094
Abstract: Zhang et al. recently proposed a new mechanism of metabolism‐secretion coupling impairment in diabetic β‐cells involving the loss of cytosolic adenosine triphosphate by leakage through plasma membrane. Hyperglycemia increases mistargeting expression of the adenosine triphosphate‐conducting… read more here.
Keywords: cytosolic adenosine; metabolism secretion; loss cytosolic; secretion coupling ... See more keywords
Utility of the RIG-I Agonist Triphosphate RNA for Melanoma Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-1262
Abstract: The pattern recognition receptor RIG-I plays an important role in the recognition of nonself RNA and antiviral immunity. RIG-I's natural ligand, triphosphate RNA (ppp-RNA), is proposed to be a valuable addition to the growing arsenal… read more here.
Keywords: treatment; melanoma; triphosphate; rna ... See more keywords
An Improved Approach for Practical Synthesis of 5-Hydroxymethyl-2′-deoxycytidine (5hmdC) Phosphoramidite and Triphosphate
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030749
Abstract: 5-Hydroxymethyl-2′-deoxycytidine (5hmdC) phosphoramidite and triphosphate are important building blocks in 5hmdC-containing DNA synthesis for epigenetic studies. However, efficient and practical methods for the synthesis of these compounds are still limited. The current research provides an… read more here.
Keywords: hydroxymethyl deoxycytidine; phosphoramidite triphosphate; deoxycytidine 5hmdc; triphosphate ... See more keywords