Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence
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DOI: 10.1016/j.ejphar.2019.01.036
Abstract: &NA; The role of 2,4‐diamino‐6‐hydroxypyrimidine (DAHP), on cellular‐senescence remains unclear as differential effects of DAHP have been reported in cardiovascular and cerebrovascular systems. We investigated the effect of pharmacologically‐induced guanosine‐triphosphate‐cyclohydrolase1 (GTPCH1)‐inhibition, through DAHP, on cellular‐senescence… read more here.
Keywords: guanosine triphosphate; triphosphate cyclohydrolase1; phosphorylation caveolin1; senescence ... See more keywords