Triple‐Combination Immunogenic Nanovesicles Reshape the Tumor Microenvironment to Potentiate Chemo‐Immunotherapy in Preclinical Cancer Models
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204890
Abstract: Immune checkpoint blockade (ICB) therapies have had a tremendous impact on cancer therapy. However, most patients harbor a poorly immunogenic tumor microenvironment (TME), presenting overwhelming de novo refractoriness to ICB inhibitors. To address these challenges,… read more here.
Keywords: combination; triple combination; tumor microenvironment; tumor ... See more keywords
Triple combination targeting methyltransferase, BCL‐2, and PD‐1 facilitates antileukemia responses in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34566
Abstract: A recent breakthrough therapy combining the BCL‐2 inhibitor venetoclax with hypomethylating agents (HMAs) targeting DNA methyltransferase has improved outcomes for patients with acute myeloid leukemia (AML), but the responses and long‐term survival in older/unfit patients… read more here.
Keywords: myeloid leukemia; triple combination; acute myeloid; methyltransferase ... See more keywords
Overcoming Bioavailability Challenges of Dasabuvir and Enabling a Triple-Combination Direct-Acting Antiviral HCV Regimen through a Salt of Very Weak Acid for Oral Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00161
Abstract: Dasabuvir is a non-nucleoside polymerase inhibitor for the treatment of hepatitis C virus (HCV) infection. It is an extremely weak diacidic drug (pKa = 8.2 and 9.2) and a prolific solvate former. Due to its… read more here.
Keywords: dasabuvir; triple combination; oral delivery; combination direct ... See more keywords
LONG-TERM EFFECT OF DIFFERENT TRIPLE COMBINATION ANTIHYPER-TENSIVE MEDICATIONS: DATA FROM THE BRISIGHELLA HEART STUDY
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000837636.80750.dd
Abstract: Objective: The aim of this study was to comparatively evaluate clinical, laboratory and hemodynamic effects on the long term of different triple combination antihypertensive medications in a well-characterized population cohort. Design and method: We considered… read more here.
Keywords: long term; different triple; combination; triple combination ... See more keywords
A split face comparative study using a novel triple combination therapy for the treatment of persistent post acne erythema
Sign Up to like & getrecommendations! Published in 2022 at "Dermatologic Therapy"
DOI: 10.1111/dth.15327
Abstract: Persistent post acne erythema (PAE) is common cosmetically unacceptable and challenging sequelae of acne lesions. Tranexamic acid (TXA) is an antifibrinolytic agent that shows a positive effect on wound healing in several studies, and it… read more here.
Keywords: triple combination; pae; treatment persistent; treatment ... See more keywords
In vitro antidermatophytic synergism of double and triple combination of clioquinol with ciclopirox and terbinafine
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DOI: 10.1111/myc.13127
Abstract: Dermatophytoses are the most frequent fungal infections worldwide and there have been described clinical resistance to the commonly used antifungals. Clioquinol is an antimicrobial that had the oral formulations withdrawn from the market in the… read more here.
Keywords: vitro antidermatophytic; double triple; antidermatophytic synergism; combination clioquinol ... See more keywords
Triple‐combination clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel for moderate‐to‐severe acne in children and adolescents: Randomized phase 2 study
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric Dermatology"
DOI: 10.1111/pde.15283
Abstract: Topical clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel (IDP‐126) is the first fixed‐dose triple‐combination formulation in development for acne. This post hoc analysis investigated efficacy and safety of IDP‐126 in children and adolescents with moderate‐to‐severe… read more here.
Keywords: peroxide adapalene; triple combination; phosphate benzoyl; clindamycin phosphate ... See more keywords
Evaluation of the safety and efficacy of a triple combination cream (hydroquinone, tretinoin, and fluocinolone) for treatment of melasma in Middle Eastern skin
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DOI: 10.2147/ccid.s202285
Abstract: Background: Melasma is the most common pigmentary skin disorder, especially in females and those with darker complexion. The current study evaluated the safety and efficacy of a triple combination cream containing hydroquinone 4%+tretinoin 0.05%+fluocinolone acetonide… read more here.
Keywords: cream; treatment; melasma; triple combination ... See more keywords
Selexipag-based triple combination therapy improves prognosis in Chinese pulmonary arterial hypertension patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.991586
Abstract: Aim Selexipag is an oral selective prostacyclin receptor agonist approved for treatment of patients with pulmonary arterial hypertension (PAH). In the present study, we aim to assess the safety and efficacy of selexipag in triple… read more here.
Keywords: pulmonary arterial; hypertension; triple combination; combination therapy ... See more keywords
Modeling of pulmonary deposition of agents of open and fixed dose triple combination therapies through two different low-resistance inhalers in COPD: a pilot study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1065072
Abstract: Introduction Inhalation therapy is a cornerstone of treating patients with chronic obstructive pulmonary disease (COPD). Inhaler devices might influence the effectiveness of inhalation therapy. We aimed to model and compare the deposition of acting agents… read more here.
Keywords: copd; agents open; fixed dose; combination ... See more keywords
Comparative efficacy of triple combination therapies containing either bortezomib or rituximab in treatment naïve patients with lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia
Sign Up to like & getrecommendations! Published in 2023 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v22i3.24
Abstract: Purpose: To evaluate the comparative efficacy of triple combination therapies of cyclophosphamide/dexamethasone containing either bortezomib or rituximab in treatment-naïve patients diagnosed with lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia, LPL/WM). Methods: Symptomatic, untreated patients with LPL/WM diagnosed in… read more here.
Keywords: comparative efficacy; triple combination; efficacy; group ... See more keywords