Efficient secretory expression of type III recombinant human collagen with triple-helical structure in Komagataella phaffii
Sign Up to like & getrecommendations! Published in 2025 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-025-13566-3
Abstract: Recombinant human collagen (rhCol) holds broad potential in biomedical and industrial applications due to its high purity and low immunogenicity. However, large-scale production of structurally stable and functionally active rhCol remains challenging. A novel strategy… read more here.
Keywords: triple helical; collagen; recombinant human; expression ... See more keywords
Fabrication of tumor-targeting composites based on the triple helical β-glucan through conjugation of aptamer.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.117476
Abstract: Herein the nucleic acid aptamers were attached to the polydeoxyadenylic acid (poly(dA)) tail for improving the tumor-targetability and cellular internalization of s-LNT/poly(dA) composite composed of two single chains of triple helical β-glucan lentinan (s-LNT) and… read more here.
Keywords: helical glucan; lnt; poly; triple helical ... See more keywords
Experimental investigation on the VIV of two side-by-side risers fitted with triple helical strakes under coupled interference effect
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Fluids and Structures"
DOI: 10.1016/j.jfluidstructs.2020.103202
Abstract: Abstract Triple helical strakes have been proved to be highly effective in suppressing the vortex-induced vibration (VIV) of isolated riser. Nevertheless, when risers work in clusters, interference effect can give rise to more complicated flow-induced… read more here.
Keywords: effect; side side; helical strakes; triple helical ... See more keywords
The 2-Aminopyridine Nucleobase Improves Triple-Helical Recognition of RNA and DNA When Used Instead of Pseudoisocytosine in Peptide Nucleic Acids.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00275
Abstract: Pseudoisocytosine (J), a neutral analogue of protonated cytosine, is currently the gold standard modified nucleobase in peptide nucleic acids (PNAs) for the formation of J·G-C triplets that are stable at physiological pH. This study shows… read more here.
Keywords: peptide nucleic; rna dna; triple helical; nucleic acids ... See more keywords
Asymmetric Triple Helical Nonbenzenoid Nanographenes with Controllable Helicene Lengths
Sign Up to like & getrecommendations! Published in 2025 at "Organic Letters"
DOI: 10.1021/acs.orglett.5c03372
Abstract: Helical nanographenes (NGs) play a crucial role in the development of chiral nanomaterials due to their distinctive optoelectronic and chiroptical properties. Herein, we report the efficient synthesis of two unprecedented azulene-embedded asymmetric triple helical NGs… read more here.
Keywords: asymmetric triple; triple helical; nanographenes controllable; controllable helicene ... See more keywords
The recognition mechanism of triple-helical β-1,3-glucan by a β-1,3-glucanase.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc03330c
Abstract: β-1,3-Glucan is one of the most abundant polysaccharides in fungi. Recognition of β-1,3-glucan occurs in both hydrolysis by glycoside hydrolases and immunological recognition. Our study provides a novel structural account of how glycoside hydrolase recognizes… read more here.
Keywords: helical glucan; recognition mechanism; recognition; glucan glucanase ... See more keywords
Rules for the design of aza-glycine stabilized triple-helical collagen peptides†
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc03003a
Abstract: The stability of the triple-helical structure of collagen is modulated by a delicate balance of effects including polypeptide backbone geometry, a buried hydrogen bond network, dispersive interfacial interactions, and subtle stereoelectronic effects. Although the different… read more here.
Keywords: collagen; collagen peptides; geometry; helical collagen ... See more keywords
A conserved strategy to attack collagen: The activator domain in bacterial collagenases unwinds triple-helical collagen
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2321002121
Abstract: Significance Collagens form the resilient backbone of the mammalian extracellular matrix. Only few proteases are able to digest collagen because of its tight triple-helical fold and high content of prolines and hydroxyprolines. Bacterial collagenases of… read more here.
Keywords: bacterial collagenases; triple helical; collagen; activator domain ... See more keywords
An outcome-defining role for the triple-helical domain in regulating collagen-I assembly
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2412948121
Abstract: Significance Collagen is the molecular scaffold for animal life. By far the most prevalent collagen is type-I—the main proteinaceous component of skin and bone. Mature collagen-I is a 2:1 heterotrimeric assembly of two distinctive collagen… read more here.
Keywords: triple helical; defining role; collagen; outcome defining ... See more keywords
ABCG5 and ABCG8 gene variations associated with sitosterolemia and platelet dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "Platelets"
DOI: 10.1080/09537104.2020.1779926
Abstract: Sitosterolemia (OMIM 210250) is a rare inherited autosomal recessive disorder of lipid metabolism, characterized by increased levels of plasma plant sterols (PS) such as stigmasterol, campesterol, and sitosterol [1,2]. Only around 100 patients with sitosterolemia… read more here.
Keywords: abcg5 abcg8; gene variations; tmd; abcg8 gene ... See more keywords
A novel method for detecting conformation-dependent β-glucans—single, double, and triple-helical from Shiitake mushroom
Sign Up to like & getrecommendations! Published in 2024 at "Natural Product Research"
DOI: 10.1080/14786419.2024.2306602
Abstract: Abstract This pioneering study explores the structural intricacies of therapeutic β-glucan in Shiitake (Lentinula edodes), i.e. Lentinan (LNT). Lentinan, a neutral polysaccharide [β-(1,3; 1,6) glucan], exists in three forms; single, double, and triple-helical, but conformation-dependent… read more here.
Keywords: triple helical; double triple; shiitake; single double ... See more keywords