Transformation of ε-HBCD with the Sphingobium Indicum enzymes LinA1, LinA2 and LinATM, a triple mutant of LinA2.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.129217
Abstract: Hexabromocyclododecanes (HBCDs) were used as flame-retardants until their ban in 2013. Among the 16 stereoisomers known, ε-HBCD has the highest symmetry. This makes ε-HBCD an interesting substrate to study the selectivity of biotransformations. We expressed… read more here.
Keywords: lina2; hbcd; triple mutant; linatm triple ... See more keywords
Triple-mutant AML: too clever by HLF?
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019001533
Abstract: In this issue of Blood, Garg et al report on their investigation of the molecular interaction between mutations affecting DNMT3A and NPM1, and internal tandem duplications (ITDs) of FLT3 in acute myeloid leukemia (AML). They… read more here.
Keywords: aml clever; triple mutant; hlf; aml ... See more keywords
Development of the triple-mutant oncolytic adenovirus for treatment of metastatic cancer by means of intravascular virus administration.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e14546
Abstract: e14546Background: Oncolytic virotherapy of cancers is a rapidly growing new area of translational research and development that has the potential to improve treatment of currently incurable maligna... read more here.
Keywords: triple mutant; mutant oncolytic; treatment; oncolytic adenovirus ... See more keywords