Evaluation of Triple-Negative Breast Cancer Early Detection via Mammography Screening and Outcomes in African American and White American Patients.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA surgery"
DOI: 10.1001/jamasurg.2019.6032
Abstract: This cohort study examines triple-negative breast cancer detection via mammography screening, treatment, and survival rates in African American and white American women. read more here.
Keywords: negative breast; breast cancer; detection via; mammography screening ... See more keywords
Hormone Receptor Status of Second Breast Cancers in Women With Triple-Negative Breast Cancer.
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DOI: 10.1001/jamasurg.2025.0100
Abstract: This cohort study investigates chemoprevention in patients with triple-negative breast cancer experiencing subsequent in-breast events. read more here.
Keywords: breast cancer; breast; hormone receptor; negative breast ... See more keywords
Genomewide binding of transcription factor Snail1 in triple‐negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12317
Abstract: Transcriptional regulation mediated by the zinc finger protein Snail1 controls early embryogenesis. By binding to the epithelial tumor suppressor CDH1 gene, Snail1 initiates the epithelial–mesenchymal transition (EMT). The EMT generates stem‐like cells and promotes invasiveness… read more here.
Keywords: negative breast; breast; snail1; breast cancer ... See more keywords
Pericyte‐secreted IGF2 promotes breast cancer brain metastasis formation
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DOI: 10.1002/1878-0261.12752
Abstract: Brain metastases are life‐threatening complications of triple‐negative breast cancer, melanoma, and a few other tumor types. Poor outcome of cerebral secondary tumors largely depends on the microenvironment formed by cells of the neurovascular unit, among… read more here.
Keywords: pericyte secreted; breast cancer; cancer cells; cancer ... See more keywords
HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer
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DOI: 10.1002/1878-0261.12856
Abstract: Dependence on glutamine and acceleration of fatty acid oxidation (FAO) are both metabolic characteristics of triple‐negative breast cancer (TNBC). With the rapid growth of tumors, accelerated glutamine catabolism depletes local glutamine, resulting in glutamine deficiency.… read more here.
Keywords: negative breast; hrd1; fatty acid; breast cancer ... See more keywords
Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12928
Abstract: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with roles in inflammation and tumorigenicity. A fraction of STAT3 localizes in mitochondria, where it augments tumorigenesis via regulation of mitochondrial functions, including… read more here.
Keywords: stat3; mitochondrial stat3; expression; antioxidant gene ... See more keywords
Autophagy inhibits cancer stemness in triple‐negative breast cancer via miR‐181a‐mediated regulation of ATG5 and/or ATG2B
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13180
Abstract: Autophagy has a dual role in the maintenance of cancer stem cells (CSCs), but the precise relationship between autophagy and cancer stemness requires further investigation. In this study, it was found that luminal and triple‐negative… read more here.
Keywords: mir 181a; triple negative; cancer stemness; cancer ... See more keywords
Nicotinamide (niacin) supplement increases lipid metabolism and ROS‐induced energy disruption in triple‐negative breast cancer: potential for drug repositioning as an anti‐tumor agent
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13209
Abstract: Metabolic dysregulation is an important hallmark of cancer. Nicotinamide (NAM), a water‐soluble amide form of niacin (vitamin B3), is currently available as a supplement for maintaining general physiologic functions. NAM is a crucial regulator of… read more here.
Keywords: metabolism; supplement; triple negative; ros ... See more keywords
Enhancing therapeutic efficacy in triple‐negative breast cancer and melanoma: synergistic effects of modulated electro‐hyperthermia (mEHT) with NSAIDs especially COX‐2 inhibition in in vivo models
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DOI: 10.1002/1878-0261.13585
Abstract: Triple‐negative breast cancer (TNBC) is a leading cause of cancer mortality and lacks modern therapy options. Modulated electro‐hyperthermia (mEHT) is an adjuvant therapy with demonstrated clinical efficacy for the treatment of various cancer types. In… read more here.
Keywords: cancer; breast cancer; meht; negative breast ... See more keywords
ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling
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DOI: 10.1002/1878-0261.70022
Abstract: Triple‐negative breast cancer (TNBC) is highly metastatic and presents clinical challenges given the lack of targeted therapies. Here, we report that the ShcD phosphotyrosine adaptor protein is upregulated in TNBC, and its expression correlates with… read more here.
Keywords: breast cancer; breast; shcd; triple negative ... See more keywords
Biomimetic Tumor Cell Membrane‐Encapsulated Nanoparticles Combine NIR‐II Photothermal Therapy and Chemotherapy for Enhanced Immunotherapy in Triple‐Negative Breast Cancer
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DOI: 10.1002/adfm.202410841
Abstract: To advance the understanding and potential treatment strategies for triple‐negative breast cancer (TNBC), particularly focusing on its high metastatic propensity and uncertain molecular targets, a biomimetic tumor cell membrane‐encapsulated nanodelivery system is developed for enhanced… read more here.
Keywords: breast cancer; negative breast; tumor; cell ... See more keywords