Evaluation of Triple-Negative Breast Cancer Early Detection via Mammography Screening and Outcomes in African American and White American Patients.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA surgery"
DOI: 10.1001/jamasurg.2019.6032
Abstract: This cohort study examines triple-negative breast cancer detection via mammography screening, treatment, and survival rates in African American and white American women. read more here.
Keywords: negative breast; breast cancer; detection via; mammography screening ... See more keywords
Genomewide binding of transcription factor Snail1 in triple‐negative breast cancer cells
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DOI: 10.1002/1878-0261.12317
Abstract: Transcriptional regulation mediated by the zinc finger protein Snail1 controls early embryogenesis. By binding to the epithelial tumor suppressor CDH1 gene, Snail1 initiates the epithelial–mesenchymal transition (EMT). The EMT generates stem‐like cells and promotes invasiveness… read more here.
Keywords: negative breast; breast; snail1; breast cancer ... See more keywords
Pericyte‐secreted IGF2 promotes breast cancer brain metastasis formation
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DOI: 10.1002/1878-0261.12752
Abstract: Brain metastases are life‐threatening complications of triple‐negative breast cancer, melanoma, and a few other tumor types. Poor outcome of cerebral secondary tumors largely depends on the microenvironment formed by cells of the neurovascular unit, among… read more here.
Keywords: pericyte secreted; breast cancer; cancer cells; cancer ... See more keywords
HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer
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DOI: 10.1002/1878-0261.12856
Abstract: Dependence on glutamine and acceleration of fatty acid oxidation (FAO) are both metabolic characteristics of triple‐negative breast cancer (TNBC). With the rapid growth of tumors, accelerated glutamine catabolism depletes local glutamine, resulting in glutamine deficiency.… read more here.
Keywords: negative breast; hrd1; fatty acid; breast cancer ... See more keywords
Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer
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DOI: 10.1002/1878-0261.12928
Abstract: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with roles in inflammation and tumorigenicity. A fraction of STAT3 localizes in mitochondria, where it augments tumorigenesis via regulation of mitochondrial functions, including… read more here.
Keywords: stat3; mitochondrial stat3; expression; antioxidant gene ... See more keywords
Autophagy inhibits cancer stemness in triple‐negative breast cancer via miR‐181a‐mediated regulation of ATG5 and/or ATG2B
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DOI: 10.1002/1878-0261.13180
Abstract: Autophagy has a dual role in the maintenance of cancer stem cells (CSCs), but the precise relationship between autophagy and cancer stemness requires further investigation. In this study, it was found that luminal and triple‐negative… read more here.
Keywords: mir 181a; triple negative; cancer stemness; cancer ... See more keywords
Nicotinamide (niacin) supplement increases lipid metabolism and ROS‐induced energy disruption in triple‐negative breast cancer: potential for drug repositioning as an anti‐tumor agent
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DOI: 10.1002/1878-0261.13209
Abstract: Metabolic dysregulation is an important hallmark of cancer. Nicotinamide (NAM), a water‐soluble amide form of niacin (vitamin B3), is currently available as a supplement for maintaining general physiologic functions. NAM is a crucial regulator of… read more here.
Keywords: metabolism; supplement; triple negative; ros ... See more keywords
A Honeycomb-Like Bismuth/Manganese Oxide Nanoparticle with Mutual Reinforcement of Internal and External Response for Triple-Negative Breast Cancer Targeted Therapy.
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DOI: 10.1002/adhm.202100518
Abstract: Triple-negative breast cancer (TNBC) exhibits aggressive behavior and high levels of metastasis owing to its complex heterogeneous structure and lack of specific receptors. Here, tumor cell membrane (CM)-coated bismuth/manganese oxide nanoparticles (NPs) with high indocyanine… read more here.
Keywords: negative breast; response; breast cancer; external response ... See more keywords
Versatile Red Blood Cells for Triple‐Negative Breast Cancer Treatment via Stepwise Photoactivations
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DOI: 10.1002/adhm.202201690
Abstract: Phototherapies have many advantages for triple‐negative breast cancer (TNBC) treatment. However, their effects are often limited by short blood circulation time, poor tumor selectivity and weak penetration of phototherapeutic agents, and tumor hypoxia. For overcoming… read more here.
Keywords: red blood; triple negative; breast cancer; blood ... See more keywords
Drug Self-Delivery Nanocubes Enhance O2 -Economized Photodynamic-Immunotherapy of Triple-Negative Breast Cancer by Downregulating Wnt/β-catenin Signaling.
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DOI: 10.1002/adhm.202203019
Abstract: Although the combination of chemotherapy and immune checkpoint inhibitors (ICIs) can treat triple-negative breast cancer (TNBC), the severe effects of chemotherapy on immune cells significantly reduce the efficacy of the ICIs. Photodynamic therapy (PDT) with… read more here.
Keywords: wnt catenin; triple negative; breast cancer; catenin signaling ... See more keywords
A Mitochondria-Targeted Ferroptosis Inducer Activated by Glutathione-Responsive Imaging and Depletion for Triple Negative Breast Cancer Theranostics.
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DOI: 10.1002/adhm.202300220
Abstract: Ferroptosis is a new type of iron-dependent programmed cell death characterized by glutathione (GSH) depletion, selenoprotein glutathione peroxidase 4 (GPX4) inactivation and lipid peroxides accumulation. Mitochondria, as the main source of intracellular energy supply and… read more here.
Keywords: ferroptosis inducer; depletion; triple negative; ferroptosis ... See more keywords