The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple‐transgenic Alzheimer's disease model mice
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Toxicology"
DOI: 10.1002/tox.22498
Abstract: In recent years, neuropathological and epidemiological studies have indicated an association between Alzheimer's disease (AD) and several cardiovascular risk factors. In this study, the cardio‐protective effects of folic acid (FA) in early stage AD was… read more here.
Keywords: folic acid; alzheimer disease; triple transgenic; treatment ... See more keywords
An Adequate Supply of Bis(ethylmaltolato)oxidovanadium(IV) Remarkably Reversed the Pathological Hallmarks of Alzheimer's Disease in Triple-Transgenic Middle-Aged Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Biological trace element research"
DOI: 10.1007/s12011-021-02938-1
Abstract: Alzheimer's disease (AD) is a complex and progressive neurodegenerative disease with impaired synapse, imbalanced mineral metabolism, protein mis-folding and aggregation. Bis(ethylmaltolato)oxidovanadium(IV) (BEOV), an organic bioactive vanadium compound with low toxicity and high bioavailability, has been… read more here.
Keywords: triple transgenic; disease; alzheimer disease; bis ethylmaltolato ... See more keywords
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00464
Abstract: Alzheimer's disease (AD) is a complex neurodegenerative disorder affecting millions of people worldwide. The underlying pathologic mechanisms of AD are unclear. Over the decades, the development of single target agent did not lead to any… read more here.
Keywords: aggregation; inhibitor; alzheimer disease; triple transgenic ... See more keywords
Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.985424
Abstract: Alzheimer’s disease is the most common type of dementia, being highly prevalent in elderly women. The advanced progression may be due to decreased hormone synthesis during post-menopause as estradiol and progesterone both have neuroprotective potentials.… read more here.
Keywords: disease; alzheimer disease; month; triple transgenic ... See more keywords
Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.876816
Abstract: Emerging evidence suggests that patients with Alzheimer’s disease (AD) may show accelerated sarcopenia phenotypes. To investigate whether pathological changes associated with neuronal death and cognitive dysfunction also occur in peripheral motor neurons and muscle as… read more here.
Keywords: triple transgenic; alzheimer disease; 3xtgad mice; muscle ... See more keywords
Generation of a Triple-Transgenic Zebrafish Line for Assessment of Developmental Neurotoxicity during Neuronal Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceuticals"
DOI: 10.3390/ph12040145
Abstract: The developing brain is extremely sensitive to many chemicals. Exposure to neurotoxicants during development has been implicated in various neuropsychiatric and neurological disorders, including autism spectrum disorders and schizophrenia. Various screening methods have been used… read more here.
Keywords: triple transgenic; zebrafish line; differentiation; transgenic zebrafish ... See more keywords