Recent Progress of Triplex DNA Formation and Its Applications.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02518
Abstract: Recently, much attention has been focused on oligonucleotide drugs that precisely control the gene expression. Among these, triplex-forming oligonucleotides (TFOs) represent common antigene strategies because they bind specifically to the major groove position of genomic… read more here.
Keywords: progress triplex; recent progress; dna formation; triplex dna ... See more keywords
Ultrasensitive colorimetric detection of circulating tumor DNA using hybridization chain reaction and the pivot of triplex DNA
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44212
Abstract: This work presents an amplified colorimetric biosensor for circulating tumor DNA (ctDNA), which associates the hybridization chain reaction (HCR) amplification with G-Quadruplex DNAzymes activity through triplex DNA formation. In the presence of ctDNA, HCR occurs.… read more here.
Keywords: hybridization chain; detection; triplex dna; dna ... See more keywords
A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc08817b
Abstract: Here, we developed a coralyne-based, 'light-up' intercalator displacement assay to identify molecular stabilizers of triplex DNA using a sequence from a chromosomal breakpoint hotspot in the human c-MYC oncogene. Its potential to identify triplex DNA… read more here.
Keywords: intercalator displacement; displacement assay; triplex dna; assay detection ... See more keywords
Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra02831f
Abstract: Ryotaro Notomi, Lei Wang, Shigeki Sasaki* and Yosuke Taniguchi *a We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-20deoxycytosine and 20-deoxyguanosine base pair by triplex DNA formation. Triplex-forming… read more here.
Keywords: dna; nucleoside analogues; base pair; triplex dna ... See more keywords
Role of Hoogsteen interaction in the stability of different phases of triplex DNA.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.105.044407
Abstract: A simple coarse-grained model of DNA which includes both Watson-Crick and Hoogsteen base pairing has been used to study the melting and unzipping of triplex DNA. Using Langevin dynamics simulations, we reproduce the qualitative features… read more here.
Keywords: hoogsteen interaction; dna; role hoogsteen; triplex dna ... See more keywords
5-Substituted Flavones—Another Class of Potent Triplex DNA-Specific Ligands as Antigene Enhancers
Sign Up to like & getrecommendations! Published in 2024 at "Molecules"
DOI: 10.3390/molecules29245862
Abstract: In the field of drug development, the quest for novel compounds that bind to DNA with high affinity and specificity never ends. In the present work, we report the newest development in this field, namely,… read more here.
Keywords: dna specific; specific ligands; antigene enhancers; ligands antigene ... See more keywords
From Triads to Tools: A Comprehensive Review of the Expanding Roles of G-Triplex Structures
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30214303
Abstract: Interest in non-canonical DNA structures continues to grow, in part fueled by the recent discovery of a new structure, G-triplex DNA. Originally proposed as folding intermediates for G-quadruplex DNA, G-triplex DNA has more recently been… read more here.
Keywords: triads tools; comprehensive review; dna; triplex dna ... See more keywords