Ultrasensitive colorimetric detection of circulating tumor DNA using hybridization chain reaction and the pivot of triplex DNA
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44212
Abstract: This work presents an amplified colorimetric biosensor for circulating tumor DNA (ctDNA), which associates the hybridization chain reaction (HCR) amplification with G-Quadruplex DNAzymes activity through triplex DNA formation. In the presence of ctDNA, HCR occurs.… read more here.
Keywords: hybridization chain; detection; triplex dna; dna ... See more keywords
A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc08817b
Abstract: Here, we developed a coralyne-based, 'light-up' intercalator displacement assay to identify molecular stabilizers of triplex DNA using a sequence from a chromosomal breakpoint hotspot in the human c-MYC oncogene. Its potential to identify triplex DNA… read more here.
Keywords: intercalator displacement; displacement assay; triplex dna; assay detection ... See more keywords
Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra02831f
Abstract: Ryotaro Notomi, Lei Wang, Shigeki Sasaki* and Yosuke Taniguchi *a We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-20deoxycytosine and 20-deoxyguanosine base pair by triplex DNA formation. Triplex-forming… read more here.
Keywords: dna; nucleoside analogues; base pair; triplex dna ... See more keywords
Role of Hoogsteen interaction in the stability of different phases of triplex DNA.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.105.044407
Abstract: A simple coarse-grained model of DNA which includes both Watson-Crick and Hoogsteen base pairing has been used to study the melting and unzipping of triplex DNA. Using Langevin dynamics simulations, we reproduce the qualitative features… read more here.
Keywords: hoogsteen interaction; dna; role hoogsteen; triplex dna ... See more keywords