γ‐(S)‐Guanidinylmethyl‐Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900393
Abstract: γ‐Modified (i.e., (S)‐aminomethyl, (S)‐acetamidomethyl, (R)‐4‐(hydroxymethyl)triazol‐1‐ylmethyl, and (S)‐guanidinylmethyl) triplex‐forming peptide nucleic acids (TFPNAs) were synthesized and the effect of the backbone modifications on the binding to a miR‐215 model was studied. Among the modifications, an appropriate… read more here.
Keywords: nucleic acids; peptide nucleic; guanidinylmethyl; forming peptide ... See more keywords
Triplex forming oligonucleotides targeted to hmga1 selectively inhibit its expression and induce apoptosis in human cervical cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1160257
Abstract: High-mobility group A1 (HMGA1) is a non-histone chromosomal protein, which is known as ‘architectural’ transcription factor that facilitates the assembly of ‘enhanceosome.’ Because of its elevated expression in a number of human malignancies, with barely… read more here.
Keywords: forming oligonucleotides; triplex forming; expression; cancer ... See more keywords
Antigene and Antiproliferative Effects of Triplex-Forming Oligonucleotide (TFO) Targeted on hmgb1 Gene in Human Hepatoma Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200619170438
Abstract: BACKGROUND The high mobility group box 1 (hmgb1) is one of the frequently over-expressed genes whose aberrant expression is reported in a number of human cancers. Various strategies are underway to inhibit hmgb1 expression in… read more here.
Keywords: forming oligonucleotide; hmgb1 gene; triplex forming; tfo ... See more keywords
Recent Development in Biomedical Applications of Oligonucleotides with Triplex-Forming Ability
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DOI: 10.3390/polym15040858
Abstract: A DNA structure, known as triple-stranded DNA, is made up of three oligonucleotide chains that wind around one another to form a triple helix (TFO). Hoogsteen base pairing describes how triple-stranded DNA may be built… read more here.
Keywords: dna; triplex forming; biomedical applications; development biomedical ... See more keywords