Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome
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DOI: 10.1007/s12035-018-1046-4
Abstract: Expression of MeCP2 must be carefully regulated as a reduction or increase results in serious neurological disorders. We are studying transgenic mice in which the MeCP2 gene is expressed at about three times higher than the… read more here.
Keywords: mecp2 triplication; mecp2 mice; triplication syndrome; mice ... See more keywords