Metabonomic and transcriptomic analyses of Tripterygium glycosides tablet-induced hepatotoxicity in rats.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2022.2077360
Abstract: We aimed to explore novel biomarkers involved in alterations of metabolism and gene expression related to the hepatotoxic effects of Tripterygium glycosides tablet (TGT) in rats. Rats were randomly divided into groups based on oral… read more here.
Keywords: metabolism; glycosides tablet; hepatotoxicity; tripterygium glycosides ... See more keywords
Efficacy and safety of Tripterygium glycosides as an add-on treatment in adults with chronic urticaria: a systematic review and meta-analysis
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DOI: 10.1080/13880209.2023.2169468
Abstract: Abstract Context Tripterygium glycosides (TG), a traditional Chinese medicine, has been used to treat chronic urticaria (CU) in China, and the evidence of TG for CU needs to be updated thoroughly. Objective To systematically evaluate… read more here.
Keywords: efficacy; chronic urticaria; tripterygium glycosides; efficacy safety ... See more keywords
Efficacy and safety of tripterygium glycosides for Graves ophthalmopathy
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DOI: 10.1097/md.0000000000018242
Abstract: BACKGROUND Graves ophthalmopathy (GO) is one of the remaining enigmas in thyroidology. Glucocorticoids (GCs) are strongly recommended but their effects are not completely satisfactory and adverse reactions can occur. Tripterygium glycosides (TG) is a promising… read more here.
Keywords: graves ophthalmopathy; efficacy safety; tripterygium; efficacy ... See more keywords
A case of tripterygium glycosides‐associated AGEP‐like drug reaction combined with bullous pemphigoid
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DOI: 10.1111/dth.15012
Abstract: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous drug reaction. Bullous pemphigoid (BP) is an acquired autoimmune disease that might be associated with drugs. There is currently no report of tripterygium glycosides (TG)‐induced AGEP‐like… read more here.
Keywords: agep like; tripterygium glycosides; drug reaction; bullous pemphigoid ... See more keywords
Protective Effect and Possible Mechanisms of Tripterygium Glycosides in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-Analysis
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DOI: 10.1155/2022/9374895
Abstract: Objective The safety and efficacy of Tripterygium glycosides (TG) were assessed for ankylosing spondylitis (AS) in accordance with the existing literatures. Materials and Methods Electronic literature was searched from Chinese VIP databases, Cochrane Library, Chinese… read more here.
Keywords: rate; tripterygium glycosides; meta analysis; ankylosing spondylitis ... See more keywords
Targets of Tripterygium glycosides in systemic lupus erythematosus treatment: A network-pharmacology study
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DOI: 10.1177/09612033221076725
Abstract: Objective We aimed to explore the underlying mechanism of Tripterygium glycosides (TGs) in treating systemic lupus erythematosus (SLE) through network-pharmacology approach. Methods The protein targets of TGs’ three active ingredients (triptolide, tripterine, and wilforlide) and… read more here.
Keywords: sle; network; pharmacology; tripterygium glycosides ... See more keywords
Pharmacovigilance of Herb-Drug Interactions: A Pharmacokinetic Study on the Combined Administration of Tripterygium Glycosides Tablets and Leflunomide Tablets in Rats by LC-MS/MS
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DOI: 10.3390/ph15080991
Abstract: A popular and widely used combination therapy of leflunomide (LEF) and Tripterygium glycosides tablets (TGTS) has become a valuable clinical tool in China for the treatment of rheumatoid arthritis. This regimen has not been evaluated… read more here.
Keywords: administration; drug interactions; glycosides tablets; herb drug ... See more keywords