Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Research Reviews"
DOI: 10.1002/med.21762
Abstract: Tripterygium wilfordii Hook F (TwHF)‐based therapy is among the most efficient and crucial therapeutics for the treatment of rheumatoid arthritis (RA), which indicates that TwHF is a potential source of novel anti‐RA drugs. However, accumulating… read more here.
Keywords: medicine; treatment; tripterygium wilfordii; rheumatoid arthritis ... See more keywords
Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers of Medicine"
DOI: 10.1007/s11684-018-0649-5
Abstract: Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical… read more here.
Keywords: clinical practice; tripterygium wilfordii; twhf extracts; wilfordii hook ... See more keywords
Enhanced production of celastrol in Tripterygium wilfordii hairy root cultures by overexpression of TwSQS2
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2020.107681
Abstract: Abstract Celastrol with various bioactivities is a triterpenoid compound derived from Tripterygium wilfordii which is an important medicinal plant. The limited resources restrict the industrialization of celastrol. To enhance the content of celastrol, a new… read more here.
Keywords: celastrol; twsqs2; tripterygium wilfordii; hairy ... See more keywords
Dihydro-β-agarofuran sesquiterpenoid derivatives with anti-inflammatory activity from the leaves of Tripterygium wilfordii.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103288
Abstract: Triptersinoids A-E (1-5), five undescribed highly oxygenated dihydro-β-agarofuran type sesquiterpenoid polyesters, along with three known analogues were isolated from the aqueous EtOH extracts of the dried leaves of Tripterygium wilfordii. Spectroscopic techniques were used for… read more here.
Keywords: anti inflammatory; leaves tripterygium; dihydro agarofuran; tripterygium wilfordii ... See more keywords
Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.08.072
Abstract: The aim of this study was to verify the effects of TwIDI (GenBank: KT279355.1) on triptolide and celastrol accumulation in the biosynthesis of terpenoids in Tripterygium wilfordii and the regulation of the expression of related… read more here.
Keywords: overexpression; tripterygium wilfordii; group; celastrol ... See more keywords
Agrobacterium rhizogenes-mediated RNAi of Tripterygium wilfordii and application for functional study of terpenoid biosynthesis pathway genes
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2019.111509
Abstract: Abstract Tripterygium wilfordii is an important medical plants which is rich in several valuable bioactive terpenoids, such as triptolide and wilforine. Developing a fast and efficient transformation method is imperative for exploring these metabolites biosynthesis… read more here.
Keywords: biosynthesis pathway; tripterygium; tripterygium wilfordii; agrobacterium rhizogenes ... See more keywords
Rapid identification of triptolide in Tripterygium wilfordii products by gold immunochromatographic assay
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.02.020
Abstract: Graphical abstract Figure. No caption available. HighlightsA colloidal gold immunochromatographic strip method for triptolide test was established for the first time.GICA has the advantages of portability, simple operation, rapid detection, and immediate visualization of test… read more here.
Keywords: strip; tripterygium wilfordii; gold immunochromatographic; colloidal gold ... See more keywords
Simultaneous detection of Tripterygium wilfordii sesquiterpene alkaloids by microemulsion electrokinetic chromatography coupled with large volume sample stacking
Sign Up to like & getrecommendations! Published in 2019 at "Microchemical Journal"
DOI: 10.1016/j.microc.2019.04.073
Abstract: Abstract A new simple, rapid and sensitive method using microemulsion electrokinetic chromatography (MEEKC) coupled with large volume sample stacking (LVSS) for the detection of five Tripterygium wilfordii sesquiterpene alkaloids (peritassine A, wilforgine, wilfordine, triptonine B… read more here.
Keywords: volume sample; large volume; tripterygium wilfordii; detection ... See more keywords
A specific UDP-glucosyltransferase catalyzes the formation of triptophenolide glucoside from Tripterygium wilfordii Hook. f.
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.112062
Abstract: Tripterygium wilfordii Hook. f. is a perennial woody vine member of the Celastraceae family. As a traditional Chinese medicine, it contains complex chemical components and exerts various pharmacological activities. In the present study, we identified… read more here.
Keywords: triptophenolide glucoside; tripterygium wilfordii; glucosyltransferase; wilfordii hook ... See more keywords
Differential expression of the TwHMGS gene and its effect on triptolide biosynthesis in Tripterygium wilfordii.
Sign Up to like & getrecommendations! Published in 2019 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(19)30059-7
Abstract: 3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is the first committed enzyme in the MVA pathway and involved in the biosynthesis of terpenes in Tripterygium wilfordii. The full-length cDNA and a 515 bp RNAi target fragment of TwHMGS were… read more here.
Keywords: expression; expression twhmgs; differential expression; tripterygium wilfordii ... See more keywords
Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(21)60078-x
Abstract: Tripterygium wilfordii multiglycoside (GTW) is a commonly used compound for the treatment of rheumatoid arthritis (RA) and immune diseases in clinical practice. However, it can induce liver injury and the mechanism of hepatotoxicity is still… read more here.
Keywords: apoptosis; tripterygium wilfordii; inflammation; wilfordii multiglycoside ... See more keywords