Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.08.072
Abstract: The aim of this study was to verify the effects of TwIDI (GenBank: KT279355.1) on triptolide and celastrol accumulation in the biosynthesis of terpenoids in Tripterygium wilfordii and the regulation of the expression of related… read more here.
Keywords: overexpression; tripterygium wilfordii; group; celastrol ... See more keywords
A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
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DOI: 10.3389/fphar.2018.00104
Abstract: Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide… read more here.
Keywords: natural products; tripterygium wilfordii; wilfordii hook; celastrol ... See more keywords
The therapeutic potential of triptolide and celastrol in neurological diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1024955
Abstract: Neurological diseases are complex diseases affecting the brain and spinal cord, with numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook. F. (TWHF) is a traditional Chinese medicine with a long history of… read more here.
Keywords: celastrol neurological; triptolide celastrol; potential triptolide; therapeutic potential ... See more keywords