Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-018-9447-8
Abstract: AbstractTriptolide being an active ingredient of Chinese herbal plant Tripterygium wilfordii Hook f. has severe hepatotoxicity. Previous studies from our lab reported triptolide-induced mitochondrial toxicity in hepatocytes. However, biomolecular mechanisms involved in triptolide-induced mitochondrial dysfunction… read more here.
Keywords: induced hepatotoxicity; novel mechanism; triptolide induced; hepatotoxicity ... See more keywords
Protective Effect of Vitamin C on Triptolide-induced Acute Hepatotoxicity in Mice through mitigation of oxidative stress.
Sign Up to like & getrecommendations! Published in 2019 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765201920181257
Abstract: Triptolide, a purified diterpenoid from the herb Tripterygium wilfordii Hook.f., was widely used to treat many diseases. However, the hepatotoxicity of triptolide limited its clinical use. Research showed oxidative stress played an important role in… read more here.
Keywords: vitamin; hepatotoxicity; triptolide induced; oxidative stress ... See more keywords
The molecular pathogenesis of triptolide-induced hepatotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.979307
Abstract: Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity. Furthermore, TP-induced… read more here.
Keywords: molecular pathogenesis; hepatotoxicity; pathogenesis triptolide; triptolide induced ... See more keywords
Macrophage malfunction in Triptolide-induced indirect hepatotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.981996
Abstract: Background and Objective: Indirect hepatotoxicity is a new type of drug-induced hepatotoxicity in which the character of a drug that may induce its occurrence and the underlying mechanism remains elusive. Previously, we proved that Triptolide… read more here.
Keywords: induced indirect; indirect hepatotoxicity; hepatotoxicity; inflammatory factors ... See more keywords