Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4137497
Abstract: In this work, a series of water-soluble triptolide prodrugs were synthesized, and their triptolide release rate, pharmacokinetic characteristics and anti-tumor effect were measured. We found that inserting glycolic acid as a linker between triptolide and… read more here.
Keywords: water; release triptolide; human acute; triptolide prodrug ... See more keywords
TP-CSO: A Triptolide Prodrug for Pancreatic Cancer Treatment
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DOI: 10.3390/molecules27123686
Abstract: Triptolide (TP) is a potential drug candidate for the treatment of cancer, but its use was hampered by its systemic toxicity and poor water solubility. Hence, a TP-CSO prodrug was synthesized by conjugating TP to… read more here.
Keywords: cso; triptolide prodrug; cso triptolide; prodrug pancreatic ... See more keywords