Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216857120
Abstract: Inositol 1,4,5-trisphosphate receptors (IP3Rs) are one of the two types of tetrameric ion channels that release calcium ion (Ca2+) from the endoplasmic reticulum (ER) into the cytosol. Ca2+ released via IP3Rs is a fundamental second… read more here.
Keywords: endoplasmic reticulum; inositol trisphosphate; activity; trisphosphate receptors ... See more keywords
Inositol 1,4,5-trisphosphate receptors in cardiomyocyte physiology and disease
Sign Up to like & getrecommendations! Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2021.0319
Abstract: The contraction of cardiac muscle underlying the pumping action of the heart is mediated by the process of excitation-contraction coupling (ECC). While triggered by Ca2+ entry across the sarcolemma during the action potential, it is… read more here.
Keywords: inositol trisphosphate; cardiomyocyte physiology; physiology; trisphosphate receptors ... See more keywords
Abstract MP150: Inositol 1,4,5-trisphosphate Receptors Selectively Regulate Detrimental Cardiac Fibrosis by Modulating ER-phagy
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.mp150
Abstract: Background: Therapeutic strategies that specifically target excessive post-ischemic cardiac fibrosis are lacking but desperately needed; thus, it is critical to understand the molecular mechanisms underlying these processes. Genome-wide association studies have revealed an association between… read more here.
Keywords: trisphosphate receptors; fibrosis; post ischemic; ischemic cardiac ... See more keywords