Ene Reactions of Nitrosocarbonyl Intermediates with Trisubstituted Cycloalkenes: “Cis Effect” and Steric and Conformational Factors Drive the Selectivity
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DOI: 10.1021/acsomega.7b01124
Abstract: Nitrosocarbonyl intermediates, generated at room temperature by oxidation of nitrile oxides, undergo clean ene reactions with trisubstituted cycloalkenes. Nitrosocarbonyl benzene follows a Markovnikov orientation and abstracts preferentially the twix hydrogens over the lone ones. With… read more here.
Keywords: trisubstituted cycloalkenes; ene reactions; nitrosocarbonyl intermediates; effect ... See more keywords