Synthesis of Trisubstituted Furans via Copper(I)-Catalyzed Strain-Driving Cycloisomerization/Annulative Fragmentation.
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DOI: 10.1021/acs.orglett.2c00578
Abstract: The in situ formed furan-fused cyclobutenes via Cu(I)-catalyzed cycloisomerization of readily available allenyl ketones bearing a cyclopropyl moiety are a highly reactive and powerful species, which undergo annulative fragmentation with terminal ynones to afford a… read more here.
Keywords: synthesis trisubstituted; trisubstituted furans; strain; cycloisomerization ... See more keywords