Preparation of 2,4,5-Trisubstituted Oxazoles through Iodine-mediated Aerobic Oxidative Cyclization of Enaminones.
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DOI: 10.1021/acs.orglett.8b00376
Abstract: A novel approach to trisubstituted oxazoles has been developed that is based upon an iodine-mediated aerobic oxidative cyclization of enaminone derivatives. This transition-metal-free procedure was highly efficient and involved the removal of four hydrogen atoms… read more here.
Keywords: iodine mediated; aerobic oxidative; mediated aerobic; trisubstituted oxazoles ... See more keywords
An umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition of aryl aldehydes and nitriles: a facile access to 2,4,5-trisubstituted oxazoles
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc00046f
Abstract: We have described the first example of an umpolung strategy for intermolecular [2 + 2 + 1] cycloaddition between two aryl aldehydes and a nitrile under the influence of TMSOTf that proceeds through the formation… read more here.
Keywords: strategy intermolecular; intermolecular cycloaddition; trisubstituted oxazoles; umpolung strategy ... See more keywords