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Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02606
Abstract: Disclosed herein is an efficient strategy for the synthesis of 2,4,5-trisubstituted pyridines via CuI/NBS-catalyzed formal intermolecular [2+2+2] cycloaddition of easily available primary amines and nonactivated terminal alkynes. Moreover, this given reaction features a new mode…
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Keywords:
catalyzed formal;
regio chemoselective;
chemoselective copper;
trisubstituted pyridines ... See more keywords
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Published in 2018 at "Synthetic Communications"
DOI: 10.1080/00397911.2017.1410174
Abstract: ABSTRACT For the application in organic electronics as well as pH meters, a series of novel 2,4,6-trisubstituted pyridines have been synthesized by the reaction of substituted aromatic aldehydes and substituted 3-acetylcoumarin with ammonium acetate. The…
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Keywords:
design synthesis;
trisubstituted pyridines;
photophysical chemosensor;
novel trisubstituted ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27051746
Abstract: A three-step synthetic route giving access to nonsymmetrical bisazolyl 2,4,6-trisubstituted pyridines with different substituents on the pyrazole, indazole, and pyridine heterocycles is described. From the readily available 4-bromo-2,6-difluoropyridine, both fluorine atoms allow for easy selective…
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Keywords:
trisubstituted pyridines;
synthetic approach;
orthogonal synthetic;
nonsymmetrical bisazolyl ... See more keywords