Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00664
Abstract: In this study, 70 new seco-lupane triterpene derivatives were designed, synthesized, and characterized, and their in vitro anticancer activities were evaluated. Structure-activity relationship studies showed that most compounds inhibited the growth of a variety of… read more here.
Keywords: cycle; triterpene derivatives; cell cycle; lupane triterpene ... See more keywords
3,4-seco-lupane triterpene derivatives with cytotoxic activities from the leaves of Eleutherococcus sessiliflorus
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DOI: 10.1080/14786419.2019.1656622
Abstract: Abstract A new 3,4-seco-lupane triterpene, named sessiligenin (1), along with four known 3,4-seco-lupane triterpene derivatives (chiisanogenin 2, chiisanoside 3, divaroside 4, and sessiliside-A1 5) were isolated from the ethanol extract of the leaves of Eleutherococcus… read more here.
Keywords: leaves eleutherococcus; lupane triterpene; triterpene derivatives; seco lupane ... See more keywords
Antimicrobial Activity of two Semisynthetic Triterpene Derivatives from Euphorbia Officinarum Latex Against Fungal and Bacterial Phytopathogens
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DOI: 10.1177/1934578x1701200305
Abstract: This study evaluated the in vitro antimicrobial effect of 3β-acetoxy-norlup-20-one (1) and 3-chloro-4α,14α-dimethyl-5α-cholest-8-ene (2), triterpene derivatives from Euphorbia officinarum latex against fungal and bacterial phytopathogens. Results showed that although mycelial growth of several strains of… read more here.
Keywords: triterpene derivatives; euphorbia officinarum; officinarum latex; fungal bacterial ... See more keywords
Triterpene Derivatives as Potential Inhibitors of the RBD Spike Protein from SARS-CoV-2: An In Silico Approach
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DOI: 10.3390/molecules28052333
Abstract: The appearance of a new coronavirus, SARS-CoV-2, in 2019 kicked off an international public health emergency. Although rapid progress in vaccination has reduced the number of deaths, the development of alternative treatments to overcome the… read more here.
Keywords: potential inhibitors; triterpene derivatives; rbd spike; spike protein ... See more keywords
New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.161
Abstract: Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing a 1,2,4-triazole-3-carboxamide moiety, is a first-line drug for its treatment, however, its clinical… read more here.
Keywords: new triazole; triterpene derivatives; molecular modeling; rsv ... See more keywords