Tropomyosin-Related Kinase Receptor and Neurotrophin Expression in Cutaneous Melanoma Is Associated with a Poor Prognosis and Decreased Survival
Sign Up to like & getrecommendations! Published in 2019 at "Oncology"
DOI: 10.1159/000499384
Abstract: Objective: Normally, activation of tropomyosin-related kinase (TRK) receptors by neurotrophins (NTs) stimulates intracellular pathways involved in cell survival and proliferation. Dysregulation of NT/TRK signaling may affect neoplasm prognosis. Data on NT and TRK expression in… read more here.
Keywords: melanoma; trk expression; prognosis; related kinase ... See more keywords
Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells
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DOI: 10.1186/s40659-018-0167-6
Abstract: AbstractBackgroundArsenic trioxide (As2O3), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor (Trk) family… read more here.
Keywords: induces cell; trk expression; time; cell cycle ... See more keywords
The Diagnostic Value of Pan-Trk Expression to Detect Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion in CNS Tumours: A Study Using Next-Generation Sequencing Platform
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DOI: 10.3389/pore.2022.1610233
Abstract: Background: Neurotrophic tyrosine receptor kinase (NTRK) fusion has been detected in rare types of CNS tumours, which can promote tumorigenesis. The efficacy of Trk inhibitor became a significant therapeutic interest. Our aim was to investigate… read more here.
Keywords: cns tumours; fusion; pan; pan trk ... See more keywords
NTRK Fusions in 1113 Solid Tumors in a Single Institution
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DOI: 10.3390/diagnostics12061450
Abstract: Simple Summary Recently, there has been increasing interest in identifying NTRK fusions in various tumors, as they are therapeutically targetable driver mutations. In tumor types with low-frequency NTRK fusions, recent recommendations on NTRK testing recommend… read more here.
Keywords: trk expression; ntrk fusions; pan trk; 1113 solid ... See more keywords