Nerve growth factor receptor TrkA signaling in streptozotocin-induced type 1 diabetes rat brain.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.162
Abstract: Previous work from our lab demonstrated a new role of TrkA in the insulin signaling pathway. The kinase activity of TrkA is essential for its interaction with the insulin receptor (IR) and insulin receptor substrate-1… read more here.
Keywords: insulin; trka; streptozotocin; receptor ... See more keywords
BDE-47 induced PC-12 cell differentiation via TrkA downstream pathways and caused the loss of hippocampal neurons in BALB/c mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.126850
Abstract: As the most abundant congener of polybrominated diphenyl ethers (PBDEs) detected in environment and human biotic samples, 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) has been found to accumulate in brain and induce neurotoxicity, however, the… read more here.
Keywords: bde; trka; differentiation; bde induced ... See more keywords
Optical Activation of TrkA Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00126
Abstract: Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. The pathway is implicated in neurodegenerative disorders including Alzheimer's disease, chronic pain, inflammation, and cancer. NGF… read more here.
Keywords: ngf trka; trka; activation trka; trka signaling ... See more keywords
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09744-3
Abstract: Early childhood is a critical period for development, and early life stress may increase the risk of gastrointestinal diseases including irritable bowel syndrome (IBS). In rodents, neonatal maternal separation (NMS) induces bowel dysfunctions that resemble… read more here.
Keywords: gastrointestinal diseases; life stress; trka; early life ... See more keywords
Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a
Sign Up to like & getrecommendations! Published in 2019 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-019-2709-z
Abstract: BackgroundNGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus. Inhibition of NGF-TrkA is a known strategy for the treatment of pruritus. In… read more here.
Keywords: kinase; trka; identification characterization; characterization cucurbitacins ... See more keywords
Characterization of TRKA signaling in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25723
Abstract: Tropomyosin-related kinase A (TRKA) translocations have oncogenic potential and have been found in rare cases of solid tumors. Accumulating evidence indicates that TRKA and its ligand, nerve growth factor (NGF), may play a role in… read more here.
Keywords: characterization trka; trka; aml cells; trka signaling ... See more keywords
Up-regulated GGA3 promotes non-small cell lung cancer proliferation by regulating TrkA receptor
Sign Up to like & getrecommendations! Published in 2019 at "Translational cancer research"
DOI: 10.21037/32840
Abstract: Background: GGA3 has been reported to be related to cellular events such as cell survival, cell migration and cell apoptosis through different molecular mechanisms, which imply the potential role in tumorigenesis. However, the function of… read more here.
Keywords: gga3; trka; proliferation; expression ... See more keywords
Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4185393
Abstract: Tropomyosin receptor kinase A (TrkA) is considered a therapeutic target in pain treatment, and several TrkA inhibitors have been designed and developed as potential analgesics. The subselectivity toward TrkA is closely associated with safety and… read more here.
Keywords: design development; antinociceptive effects; inhibitor; trka ... See more keywords
TrkA Co-Receptors: The Janus Face of TrkA?
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15071943
Abstract: Simple Summary NGF was the first growth factor discovered by Rita Levi Montalcini in 1950. TrkA, its high affinity receptor, is an oncogene that is overexpressed in many cancers. However, targeted therapies against TrkA, in… read more here.
Keywords: trka receptors; face trka; janus face; trka ... See more keywords
NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042124
Abstract: Nerve growth factor (NGF) and its high-affinity receptor TRKA are overexpressed in epithelial ovarian cancer (EOC) displaying a crucial role in the disease progression. Otherwise, NGF interacts with its low-affinity receptor P75, activating pro-apoptotic pathways.… read more here.
Keywords: cleavage p75; p75 ovarian; trka; p75 ... See more keywords