Amitriptyline Reduces Sepsis-Induced Brain Damage Through TrkA Signaling Pathway
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DOI: 10.1007/s12031-020-01611-x
Abstract: Sepsis can induce acute and chronic changes in the central nervous system termed sepsis-associated encephalopathy (SAE). Not only cognitive deficits but also anxiety, depression, and post-traumatic stress disorder are common in severe sepsis survivors. In… read more here.
Keywords: induced brain; sepsis; trka signaling; signaling pathway ... See more keywords
Optical Activation of TrkA Signaling.
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DOI: 10.1021/acssynbio.8b00126
Abstract: Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. The pathway is implicated in neurodegenerative disorders including Alzheimer's disease, chronic pain, inflammation, and cancer. NGF… read more here.
Keywords: ngf trka; trka; activation trka; trka signaling ... See more keywords
3β, 6β-dichloro-5-hydroxy-5α-cholestane facilitates neuronal development through modulating TrkA signaling regulated proteins in primary hippocampal neuron
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DOI: 10.1038/s41598-019-55364-8
Abstract: Potentiating neuritogenesis through pharmacological intervention might hold therapeutic promise in neurodegenerative disorders and acute brain injury. Here, we investigated the novel neuritogenic potentials of a steroidal chlorohydrin, 3β, 6β-dichloro-5-hydroxy-5α-cholestane (hereafter, SCH) and the change in… read more here.
Keywords: dichloro hydroxy; trka signaling; neuronal development; development ... See more keywords
Characterization of TRKA signaling in acute myeloid leukemia
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DOI: 10.18632/oncotarget.25723
Abstract: Tropomyosin-related kinase A (TRKA) translocations have oncogenic potential and have been found in rare cases of solid tumors. Accumulating evidence indicates that TRKA and its ligand, nerve growth factor (NGF), may play a role in… read more here.
Keywords: characterization trka; trka; aml cells; trka signaling ... See more keywords