COX‐2/PGE2 axis regulates hippocampal BDNF/TrkB signaling via EP2 receptor after prolonged seizures
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DOI: 10.1002/epi4.12409
Abstract: Abstract Objective The objective of this study was to identify the signaling pathway that is immediately triggered by status epilepticus (SE) and in turn contributes to the excessive brain‐derived neurotrophic factor (BDNF)/tropomyosin‐related kinase receptor B… read more here.
Keywords: trkb signaling; hippocampal bdnf; bdnf trkb; bdnf ... See more keywords
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice
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DOI: 10.1007/s00213-019-05287-z
Abstract: RationaleThe volatile anesthetic isoflurane is suggested to produce a rapid and robust antidepressive effect in preliminary clinical trials. Recently, isoflurane was found to activate the tropomyosin receptor kinase B (TrkB) signaling which is the underlying… read more here.
Keywords: trkb signaling; effect; bdnf trkb; isoflurane ... See more keywords
Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma.
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DOI: 10.1007/s11033-020-05739-2
Abstract: A member of the Trk family of neurotrophin receptors, tropomyosin receptor kinase B (TrkB, encoded by the NTRK2 gene) is an increasingly important target in various cancer types, including glioblastoma (GBM). EGFR is among the… read more here.
Keywords: gbm; inhibition; trkb egfr; expression ... See more keywords
The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of epilepsy
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DOI: 10.1016/j.brainresbull.2020.03.007
Abstract: Global transcriptional disturbances are believed to play a major role in the course of epilepsy. Due to the high complexity, the neurobiological mechanisms underlying different susceptibility to seizure and epilepsy are not well known. A… read more here.
Keywords: rest nrsf; role; different susceptibility; bdnf ... See more keywords
The BDNF-TrkB signaling pathway in the rostral anterior cingulate cortex is involved in the development of pain aversion in rats with bone cancer via NR2B and ERK-CREB signaling
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DOI: 10.1016/j.brainresbull.2022.04.001
Abstract: Patients with bone cancer pain (BCP) are more prone to aversion. which not only causes mental distress but also aggravates BCP. However, the mechanism of BCP-related aversion is still unclear. Previous studies have demonstrated that… read more here.
Keywords: bdnf; pain; aversion; cancer ... See more keywords
Expression and clinical significance of TrkB in sinonasal squamous cell carcinoma: a pilot study.
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DOI: 10.1016/j.ijom.2016.09.027
Abstract: Previous studies have confirmed that tropomyosin-related kinase B (TrkB) plays a critical role in the occurrence, development, and metastasis of many kinds of malignant tumour. More recently, TrkB was found to be overexpressed in head… read more here.
Keywords: cell carcinoma; squamous cell; expression; clinical significance ... See more keywords
Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice.
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DOI: 10.1016/j.molmet.2020.101149
Abstract: OBJECTIVE 7,8-Dihydroxyflavone (7,8-DHF), a small molecular mimetic of brain derived neurotrophic factor (BDNF), alleviates high-fat diet-induced obesity of female mice in a sex-specific manner by activating muscular tropomyosin-related kinase B (TrkB). However, the underlying molecular… read more here.
Keywords: trkb signaling; trkb; bdnf trkb; sex ... See more keywords
MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia
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DOI: 10.1016/j.nbd.2022.105611
Abstract: Central post-stroke pain (CPSP) and associated depression remain poorly understood and pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested to be involved in CPSP pathophysiology. The goal of this study was to investigate the… read more here.
Keywords: bdnf; hemorrhage induced; med1; depression ... See more keywords
BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the “weaver” mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.04.043
Abstract: Neurotrophic factors are among the most promising treatments aiming at slowing or stopping and even reversing Parkinson's disease (PD). However, in most cases, they cannot readily cross the human blood-brain-barrier (BBB). Herein, we propose as… read more here.
Keywords: bnn; neurotrophin receptor; bnn synthetic; trkb neurotrophin ... See more keywords
Functional expression of TrkB receptors on interneurones and pyramidal cells of area CA3 of the rat hippocampus
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DOI: 10.1016/j.neuropharm.2020.108379
Abstract: The dentate gyrus and hippocampal area CA3 region of the mammalian brain contains the highest levels of brain-derived neurotrophic factor (BDNF) and its canonical membrane receptor, tropomyosin-related kinase B (TrkB). Therefore, the present study examines… read more here.
Keywords: area ca3; interneurones pyramidal; pyramidal cells; trkb ... See more keywords
Brain-derived Neurotrophic Factor and TrkB Levels in Mice that Lack Vesicular Zinc: Effects of Age and Sex
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DOI: 10.1016/j.neuroscience.2019.11.009
Abstract: In certain neurons, zinc ions are stored in synaptic vesicles by zinc transporter 3 (ZnT3). Vesicular zinc can then be released synaptically to modulate myriad targets. In vitro evidence indicates that these targets may include… read more here.
Keywords: zinc; age; vesicular zinc; sex ... See more keywords