Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of CDKL5-Deficiency Disorders
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DOI: 10.1177/11779322231158254
Abstract: Therapeutic intervention in cyclin-dependent kinase-like 5 (CDKL5) deficiency disorders (CDDs) has remained a concern over the years. Recent advances into the mechanistic interplay of signalling pathways has revealed the role of deficient tropomyosin receptor kinase… read more here.
Keywords: virtual screening; molecular dynamics; cdkl5 deficiency; trkb agonists ... See more keywords