Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system
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DOI: 10.1007/s00213-017-4612-y
Abstract: RationaleRepeated social defeat (RSD) increases the rewarding effects of cocaine in adolescent and adult rodents.ObjectiveThe aim of the present study was to compare the long-term effects of RSD on the conditioned rewarding effects of cocaine… read more here.
Keywords: social defeat; adult; rewarding effects; trkb receptor ... See more keywords
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome
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DOI: 10.1073/pnas.2022726119
Abstract: Significance Dravet syndrome (DS) is a severe childhood epileptic encephalopathy characterized by intractable seizures and comorbidities, including a high rate of premature mortality. DS is mainly caused by loss-of-function mutations of the Scn1a gene encoding… read more here.
Keywords: function; trkb receptor; mortality; dravet syndrome ... See more keywords