COX‐2/PGE2 axis regulates hippocampal BDNF/TrkB signaling via EP2 receptor after prolonged seizures
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DOI: 10.1002/epi4.12409
Abstract: Abstract Objective The objective of this study was to identify the signaling pathway that is immediately triggered by status epilepticus (SE) and in turn contributes to the excessive brain‐derived neurotrophic factor (BDNF)/tropomyosin‐related kinase receptor B… read more here.
Keywords: trkb signaling; hippocampal bdnf; bdnf trkb; bdnf ... See more keywords
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice
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DOI: 10.1007/s00213-019-05287-z
Abstract: RationaleThe volatile anesthetic isoflurane is suggested to produce a rapid and robust antidepressive effect in preliminary clinical trials. Recently, isoflurane was found to activate the tropomyosin receptor kinase B (TrkB) signaling which is the underlying… read more here.
Keywords: trkb signaling; effect; bdnf trkb; isoflurane ... See more keywords
Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-018-0909-z
Abstract: Although depressive symptoms including anhedonia (i.e., loss of pleasure) frequently accompany pain, little is known about the risk factors contributing to individual differences in pain-induced anhedonia. In this study, we examined if signaling of brain-derived… read more here.
Keywords: pain induced; trkb signaling; anhedonia like; like phenotype ... See more keywords
Absence of Carboxypeptidase E/Neurotrophic Factor-Α1 in Knock-Out Mice Leads to Dysfunction of BDNF-TRKB Signaling in Hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0914-0
Abstract: Carboxypeptidase E (CPE), first discovered as a prohormone processing enzyme, has also now been shown to be a secreted neurotrophic factor (neurotrophic factor-α1, NF-α1) that acts extracellularly as a signaling molecule to mediate neuroprotection, cortical… read more here.
Keywords: trkb signaling; bdnf trkb; mice; neurotrophic factor ... See more keywords
Intranasal administration of transforming growth factor-β1 elicits rapid-acting antidepressant-like effects in a chronic social defeat stress model: A role of TrkB signaling
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.04.010
Abstract: (R,S)-ketamine causes rapid-acting and sustained antidepressant effects in treatment-resistant patients with depression although the precise molecular mechanisms underlying its antidepressant action remain unclear. We recently reported that transforming growth factor (TGF)-β1 might contribute to the… read more here.
Keywords: trkb signaling; rapid acting; like effects; intranasal administration ... See more keywords
Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice.
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DOI: 10.1016/j.molmet.2020.101149
Abstract: OBJECTIVE 7,8-Dihydroxyflavone (7,8-DHF), a small molecular mimetic of brain derived neurotrophic factor (BDNF), alleviates high-fat diet-induced obesity of female mice in a sex-specific manner by activating muscular tropomyosin-related kinase B (TrkB). However, the underlying molecular… read more here.
Keywords: trkb signaling; trkb; bdnf trkb; sex ... See more keywords
ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2018.08.009
Abstract: Excessive exposure to fluoride has adverse effects on neurodevelopment, but the mechanisms remain unclear. This study aimed to investigate the effects of fluoride exposure on synaptogenesis, and focused on the role of brain-derived neurotrophic factor… read more here.
Keywords: fluoride induced; disruption; trkb signaling; bdnf trkb ... See more keywords
TrkB Signaling in Dorsal Raphe Nucleus is Essential for Antidepressant Efficacy and Normal Aggression Behavior
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DOI: 10.1038/npp.2016.201
Abstract: Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB), have important roles in neural plasticity and are required for antidepressant efficacy. Studies examining the role of BDNF-TrkB signaling in depression… read more here.
Keywords: trkb signaling; trkb; antidepressant efficacy; dorsal raphe ... See more keywords
Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2022.2112439
Abstract: OBJECTIVE Depression is one of the most common complications in patients with diabetes. Our previous study demonstrated puerarin, a dietary isoflavone, improved glucose homeostasis and β-cell regeneration in high-fat diet (HFD)-induced diabetic mice. Here, we… read more here.
Keywords: depression; diabetic mice; bdnf trkb; mice ... See more keywords
Effect and Mechanism of BDNF/TrkB Signaling on Vestibular Compensation.
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DOI: 10.1080/21655979.2021.1997565
Abstract: Brain-derived neurotrophic factor (BDNF) regulates neuronal plasticity by targeting the tyrosine kinase B receptor (TrkB) receptor, but limited researches concentrate on the role of BDNF/TrkB signaling in vestibular compensation. In this study, rats with unilateral… read more here.
Keywords: bdnf trkb; trkb signaling; vestibular compensation; trkb ... See more keywords
BDNF–TrkB signaling is involved in the histopathological damage, synaptic protein loss and inflammatory response caused by an electromagnetic pulse in rat brain cortex
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DOI: 10.1097/wnr.0000000000001242
Abstract: An electromagnetic pulse (EMP) can cause central nervous system damage, but the underlying mechanisms remain unclear. In this study, we investigated the effects of EMP exposure on the cortex of the rat brain and the… read more here.
Keywords: damage; bdnf trkb; trkb; trkb signaling ... See more keywords