TrkC-CreERT2-mediated recombination supports evidence that TrkC+/TH+ DRG neurons contribute to cardiovascular homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110260
Abstract: In their Matters Arising article, McMullan et al. (2022) offer alternative explanations for the phenotypes we observed upon stimulation and ablation of TrkCCreERT2-positive neurons in mice. Their interpretations are focused on two aspects: first, whether the… read more here.
Keywords: recombination; trkc creert2; creert2 mediated; trkc ... See more keywords
The dependence receptor TrkC regulates the number of sensory neurons during DRG development.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.07.022
Abstract: The development of the sensory nervous system is the result of fine-tuned waves of neurogenesis and apoptosis which control the appropriate number of precursors and newly generated neurons and orient them toward a specific lineage.… read more here.
Keywords: dependence receptor; apoptosis; trkc; number ... See more keywords
Implication of TrkC‐miR2 in neurotrophin signalling pathway regulation through NGFR transcript targeting
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16415
Abstract: TrkC and NGFR neurotrophin receptors are associated with cell death, cancer and differentiation. TrkC‐miR2, which is located in TrkC gene, is known to regulate Wnt signalling pathway, and its influence on other signalling pathways is… read more here.
Keywords: neurotrophin signalling; trkc; signalling pathway; trkc mir2 ... See more keywords
Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Biology"
DOI: 10.1371/journal.pbio.2002912
Abstract: The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in the absence of its ligand NT-3. This proapoptotic activity has been proposed to… read more here.
Keywords: trkc; activity; proapoptotic activity; hey1 p53 ... See more keywords