Renal tubule mTORC2 deletion increases gluconeogenesis and urinary glucose excretion
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735039
Abstract: Methods: Rictor is a critical component of the mTORC2 complex. Tubule-specific Rictor knockout (TRKO) mice were made using doxycycline inducible Pax8-Cre Rictor-flox. Male and female TRKO mice and their control littermates were used for all… read more here.
Keywords: per group; trko mice; control; physiology ... See more keywords
High Potassium Suppresses Glycosuria and Gluconeogenesis in Tubule-specific mTORC2 Knockout Mice
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1589
Abstract: Background: Insulin promotes renal proximal tubule glucose reabsorption and suppresses gluconeogenesis (GNG). The kinase mTORC2 is critical for insulin signaling in multiple cell types. In the kidney tubules, mTORC2 knockout has recently been shown to… read more here.
Keywords: physiology; glucose reabsorption; mtorc2; tubule ... See more keywords