Honeybee Iflaviruses Pack Specific tRNA Fragments from Host Cells in Their Virions
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200281
Abstract: The Picornavirales include viruses that infect vertebrates, insects, and plants. It was believed that they pack only their genomic mRNA in the particles; thus, we envisaged these viruses as excellent model systems for studies of… read more here.
Keywords: specific trna; pack specific; trna fragments; iflaviruses pack ... See more keywords
Biallelic variants in CTU2 cause DREAM‐PL syndrome and impair thiolation of tRNA wobble U34
Sign Up to like & getrecommendations! Published in 2019 at "Human Mutation"
DOI: 10.1002/humu.23870
Abstract: The wobble position in the anticodon loop of transfer ribonucleic acid (tRNA) is subject to numerous posttranscriptional modifications. In particular, thiolation of the wobble uridine has been shown to play an important role in codon‐anticodon… read more here.
Keywords: dream; cause; wobble uridine; trna ... See more keywords
Evolution and variation in amide aminoacyl‐tRNA synthesis
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DOI: 10.1002/iub.2811
Abstract: The amide proteogenic amino acids, asparagine and glutamine, are two of the twenty amino acids used in translation by all known life. The aminoacyl‐tRNA synthetases for asparagine and glutamine, asparaginyl‐tRNA synthetase and glutaminyl tRNA synthetase,… read more here.
Keywords: trna; trna synthetase; synthesis; aminoacyl trna ... See more keywords
Coexisting bacterial aminoacyl‐tRNA synthetase paralogs exhibit distinct phylogenetic backgrounds and functional compatibility with Escherichia coli
Sign Up to like & getrecommendations! Published in 2024 at "IUBMB Life"
DOI: 10.1002/iub.2920
Abstract: Aminoacyl‐tRNA synthetases (aaRSs) are universally essential enzymes that synthesize aminoacyl‐tRNA substrates for protein synthesis. Although most organisms require a single aaRS gene for each proteinogenic amino acid to translate their genetic information, numerous species encode… read more here.
Keywords: escherichia coli; trna; distinct phylogenetic; aminoacyl trna ... See more keywords
Identification of variants in the mitochondrial lysine‐tRNA (MT‐TK) gene in myoclonic epilepsy—pathogenicity evaluation and structural characterization by in silico approach
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26857
Abstract: Variations in mitochondrial genes have an established link with myoclonic epilepsy. In the present study we evaluated the nucleotide sequence of MT‐TK gene of 52 individuals from 12 unrelated families and reported three variations in… read more here.
Keywords: silico; myoclonic epilepsy; pathogenicity; trna ... See more keywords
Structural and functional characterization of TrmM in m6A modification of bacterial tRNA
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4319
Abstract: N6‐methyladenosine (m6A), widely distributed in both coding and noncoding RNAs, regulates the epigenetic signals and RNA metabolism in eukaryotes. Although this posttranscriptional modification is frequently observed in messenger and ribosomal RNA, it is relatively rare… read more here.
Keywords: modification; m6a modification; trna; trmm ... See more keywords
RNA mimicry in post‐transcriptional regulation by aminoacyl tRNA synthetases
Sign Up to like & getrecommendations! Published in 2019 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1564
Abstract: Aminoacyl tRNA synthetases (aaRS) are well studied for their roles in tRNA charging with cognate amino acid. Nevertheless, numerous lines of evidence indicate that these proteins have roles other than tRNA charging. These include coordination… read more here.
Keywords: transcriptional regulation; post transcriptional; trna synthetases; aminoacyl trna ... See more keywords
Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-018-9849-9
Abstract: Bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) is an important antibacterial target due to its essential role in translation. TrmD has two domains connected with a flexible linker. The N-terminal domain (NTD) of TrmD contains the S-adenosyl-l-methionine (SAM)… read more here.
Keywords: backbone resonance; methyltransferase; trna; resonance assignment ... See more keywords
Cysteine Hydropersulfide Production Catalyzed by Cysteinyl-tRNA Synthetases
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.297
Abstract: We recently reported the production of a large quantity of reactive persulfides including cysteine hydropersulfide (CysSSH) in both prokaryotes and eukaryotes. Also, these reactive persulfides reportedly show critical functions for regulation of redox signaling. Currently,… read more here.
Keywords: trna synthetases; cysteine hydropersulfide; trna; cysteinyl trna ... See more keywords
Metabolic flux of N10-formyltetrahydrofolate plays a critical role in the fidelity of translation initiation in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.08.003
Abstract: One-carbon metabolism produces methionine and N10-formyl-tetrahydrofolate (N10-fTHF) required for aminoacylation and formylation of initiator tRNA (i-tRNA), respectively. In Escherichia coli, N10-fTHF is made from 5, 10-methylene-THF by a two-step reaction using 5,10-methylene-THF dehydrogenase/cyclohydrolase (FolD). The… read more here.
Keywords: initiation; escherichia coli; fidelity translation; trna ... See more keywords
Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00584
Abstract: Dihydrouridine (D) is an abundant modified base of tRNA found in the majority of living organisms. This base is synthesized via an NADPH-dependent reduction of specific uridines by the dihydrouridine synthases (Dus), a large family… read more here.
Keywords: dihydrouridine synthases; electrostatic potential; trna; trna binding ... See more keywords