Identification of a novel tRNA‐derived RNA fragment exhibiting high prognostic potential in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.2616
Abstract: tRNA-derived fragments (tRFs) are 16-28 nucleotide fragments, which occur by specific cleavage of tRNA molecules. i-tRF-GlyGCC is an internal tRF, originating from the tRNAs bearing the Glycine anticodon "GCC". Other tRFs generated from tRNAGlyGCC have… read more here.
Keywords: trna derived; analysis; trf; leukemia ... See more keywords
tRNA‐derived small RNA, 5'tiRNA‐Gly‐CCC, promotes skeletal muscle regeneration through the inflammatory response
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13187
Abstract: Increasing evidence shows that tRNA‐derived small RNAs (tsRNAs) are not only by‐products of transfer RNAs, but they participate in numerous cellular metabolic processes. However, the role of tsRNAs in skeletal muscle regeneration remains unknown. read more here.
Keywords: muscle; trna derived; muscle regeneration; derived small ... See more keywords
tRNA-derived fragments as new players in regulatory processes in yeast.
Sign Up to like & getrecommendations! Published in 2022 at "Yeast"
DOI: 10.1002/yea.3829
Abstract: For a very long time, RNA molecules were treated as transistory molecules, by which the genetic information flows from DNA to proteins; the model proposed in the 1960s accepted that proteins are both, the products… read more here.
Keywords: fragments new; derived fragments; noncoding rnas; trna derived ... See more keywords
tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00647-1
Abstract: tRNAs are a group of conventional noncoding RNAs (ncRNAs) with critical roles in the biological synthesis of proteins. Recently, tRNA-derived small RNAs (tsRNAs) were found to have important biological functions in the development of human… read more here.
Keywords: derived small; trna derived; cancer hallmarks; application ... See more keywords
Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-020-00211-7
Abstract: Liquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tRNA-derived small RNAs (tsRNAs) in plasma that could distinguish patients with… read more here.
Keywords: derived small; trna derived; breast cancer; small rnas ... See more keywords
Levels of seminal tRNA-derived fragments from normozoospermic men correlate with the success rate of ART.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaab017
Abstract: Decreased fertility is becoming an important social and medical problem and the male factor is involved in at least half of infertility cases. Since conventional semen analysis provides limited prediction of male fertility, in this… read more here.
Keywords: derived fragments; levels seminal; normozoospermic men; trna derived ... See more keywords
Dicer dependent tRNA derived small RNAs promote nascent RNA silencing
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac022
Abstract: Abstract In mammalian cells, small non-coding RNAs (sncRNAs) negatively regulate gene expression in a pathway known as RNA interference (RNAi). RNAi can be categorized into post-transcriptional gene silencing (PTGS), which involves the cleavage of target… read more here.
Keywords: nascent rna; small rnas; trna derived; gene ... See more keywords
The nuclear and organellar tRNA-derived RNA fragment population in Arabidopsis thaliana is highly dynamic
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1122
Abstract: Abstract In the expanding repertoire of small noncoding RNAs (ncRNAs), tRNA-derived RNA fragments (tRFs) have been identified in all domains of life. Their existence in plants has been already proven but no detailed analysis has… read more here.
Keywords: trfs; trna derived; derived rna; arabidopsis thaliana ... See more keywords
The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx537
Abstract: Abstract Transfer RNAs (tRNAs) function in translational machinery and further serves as a source of short non-coding RNAs (ncRNAs). tRNA-derived ncRNAs show differential expression profiles and play roles in many biological processes beyond translation. Molecular… read more here.
Keywords: trna halves; trna derived; expression; derived pirnas ... See more keywords
The tRNA-derived fragment 5'tRF-Gly promotes the development of hepatocellular carcinoma via direct targeting of CEACAM1.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15505
Abstract: tRNA-derived fragments are a group of small non-coding single-stranded RNA that play essential roles in multiple diseases. However, their biological functions in carcinogenesis are not well understood. In this study, 5'tRF-Gly was found to have… read more here.
Keywords: hepatocellular carcinoma; trf; ceacam1; trna derived ... See more keywords
tRNA‐derived fragment tRF‐1020 ameliorates diabetes‐induced retinal microvascular complications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17555
Abstract: Transfer RNA (tRNA)‐derived fragments are the non‐coding single‐stranded RNAs involved in several physiological and pathological processes. Herein, we investigated the role of tRF‐1020, a tRNA fragment, in diabetes‐induced retinal microvascular complications. The results showed that… read more here.
Keywords: trf; retinal microvascular; induced retinal; trf 1020 ... See more keywords