Processing by RNase 1 forms tRNA halves and distinct Y RNA fragments in the extracellular environment
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa526
Abstract: Abstract Extracellular RNAs participate in intercellular communication, and are being studied as promising minimally invasive diagnostic markers. Several studies in recent years showed that tRNA halves and distinct Y RNA fragments are abundant in the… read more here.
Keywords: trna halves; halves distinct; distinct rna; rnase ... See more keywords
The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx537
Abstract: Abstract Transfer RNAs (tRNAs) function in translational machinery and further serves as a source of short non-coding RNAs (ncRNAs). tRNA-derived ncRNAs show differential expression profiles and play roles in many biological processes beyond translation. Molecular… read more here.
Keywords: trna halves; trna derived; expression; derived pirnas ... See more keywords
5' tRNA halves are highly expressed in the primate hippocampus and might sequence-specifically regulate gene expression.
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DOI: 10.1261/rna.073395.119
Abstract: Fragments of mature tRNAs have long been considered as mere degradation products without physiological function. However, recent reports show that tRNA-derived small RNAs (tsRNAs) play prominent roles in diverse cellular processes across a wide spectrum… read more here.
Keywords: trna halves; halves highly; sequence specifically; expression ... See more keywords
Transfer RNA halves are found as nicked tRNAs in cells: evidence that nicked tRNAs regulate expression of an RNA repair operon
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079575.122
Abstract: Transfer RNA fragments are proposed to regulate numerous processes in eukaryotes, including translation inhibition, epigenetic inheritance, and cancer. In the bacterium Salmonella enterica serovar Typhimurium, 5′ tRNA halves ending in 2′,3′ cyclic phosphate are proposed… read more here.
Keywords: nicked trnas; repair operon; rna repair; trna halves ... See more keywords