Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes
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DOI: 10.1038/s41586-018-0022-5
Abstract: Ribosomal surveillance pathways scan for ribosomes that are transiently paused or terminally stalled owing to structural elements in mRNAs or nascent chain sequences1, 2. Some stalls in budding yeast are sensed by the GTPase Hbs1,… read more here.
Keywords: nascent chains; trna hydrolase; stalled ribosomes; peptidyl trna ... See more keywords
Unveiling the Druggable Landscape of Bacterial Peptidyl tRNA Hydrolase: Insights into Structure, Function, and Therapeutic Potential
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DOI: 10.3390/biom14060668
Abstract: Bacterial peptidyl tRNA hydrolase (Pth) or Pth1 emerges as a pivotal enzyme involved in the maintenance of cellular homeostasis by catalyzing the release of peptidyl moieties from peptidyl-tRNA molecules and the maintenance of a free… read more here.
Keywords: trna hydrolase; peptidyl trna; bacterial peptidyl; pth ... See more keywords