Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
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DOI: 10.1038/s41467-019-10750-8
Abstract: In bacterial tRNAs, 5-carboxymethoxyuridine (cmo5U) and its derivatives at the first position of the anticodon facilitate non-Watson–Crick base pairing with guanosine and pyrimidines at the third positions of codons, thereby expanding decoding capabilities. However, their… read more here.
Keywords: trna hydroxylation; expanding decoding; efficient translation; ho5u formation ... See more keywords
tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf719
Abstract: Abstract Post-transcriptional modification of transfer RNAs (tRNAs) represents an essential layer of translational regulation critical for bacterial adaptation to environmental changes. Increasing evidence links the tRNA epitranscriptome to pivotal roles in the regulation of gene… read more here.
Keywords: pseudomonas aeruginosa; pathogenicity; trna hydroxylation; hydroxylation epitranscriptomic ... See more keywords