Loss of tRNA methyltransferase 9 and DNA damage response genes in yeast confers sensitivity to aminoglycosides
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DOI: 10.1002/1873-3468.14591
Abstract: tRNA methyltransferase 9 (Trm9)‐catalysed tRNA modifications have been shown to translationally enhance the DNA damage response (DDR). Here, we show that Saccharomyces cerevisiae trm9Δ, distinct DNA repair and spindle assembly checkpoint (SAC) mutants are differentially… read more here.
Keywords: dna damage; dna; trna methyltransferase; damage response ... See more keywords
Reengineering a tRNA methyltransferase to covalently capture new RNA substrates.
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DOI: 10.1021/jacs.9b08529
Abstract: Covalent RNA modifications can alter the function and metabolism of RNA transcripts. Altering the RNA substrate specificities of the enzymes that install these modifications can provide powerful tools to study and manipulate RNA. To develop… read more here.
Keywords: rna substrates; rna; trna methyltransferase; trma ... See more keywords
Deciphering the Role of Residues Involved in Disorder-To-Order Transition Regions in Archaeal tRNA Methyltransferase 5
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DOI: 10.3390/genes12030399
Abstract: tRNA methyltransferase 5 (Trm5) enzyme is an S-adenosyl methionine (AdoMet)-dependent methyltransferase which methylates the G37 nucleotide at the N1 atom of the tRNA. The free form of Trm5 enzyme has three intrinsically disordered regions, which… read more here.
Keywords: order transition; trm5; disorder order; methyltransferase ... See more keywords