Probing the diversity and regulation of tRNA modifications.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2020.06.005
Abstract: Transfer RNAs (tRNAs) are non-coding RNAs essential for protein synthesis. tRNAs are heavily decorated with a variety of post-transcriptional modifications (tRNA modifications). Recent methodological advances provide new tools for rapid profiling of tRNA modifications and… read more here.
Keywords: trna modifications; chemistry; diversity regulation; regulation trna ... See more keywords
Complete chemical structures of human mitochondrial tRNAs
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18068-6
Abstract: Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two species of mitochondrial (mt-)tRNAs encoded in mtDNA translate essential subunits of the respiratory chain complexes. mt-tRNAs contain post-transcriptional modifications introduced by nuclear-encoded tRNA-modifying enzymes. They are… read more here.
Keywords: mitochondrial trnas; human mitochondrial; trna modifications; chemical structures ... See more keywords
Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31158-2
Abstract: Transfer RNA (tRNA) from all domains of life contains multiple modified nucleosides, the functions of which remain incompletely understood. Genetic interactions between tRNA modification genes in Saccharomyces cerevisiae suggest that different tRNA modifications collaborate to… read more here.
Keywords: trna modifications; factor eef1a; trna; elongation factor ... See more keywords
Autophosphorylation of conserved yeast and human casein kinase 1 isozymes regulates Elongator-dependent tRNA modifications
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf881
Abstract: Abstract Casein kinase 1 (CK1) family members are crucial for ER-Golgi trafficking, calcium signalling, DNA repair, transfer RNA (tRNA) modifications, and circadian rhythmicity. Whether and how substrate interactions and kinase autophosphorylation contribute to CK1 plasticity… read more here.
Keywords: elongator dependent; casein kinase; ck1; kinase ... See more keywords
Landscape of Post-Transcriptional tRNA Modifications in Streptomyces albidoflavus J1074 as Portrayed by Mass Spectrometry and Genomic Data Mining
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00294-22
Abstract: Post-transcriptional tRNA modifications (PTTMs) play an important role in maturation and functionality of tRNAs. Little is known about tRNA modifications in the antibiotic-producing actinobacterial genus Streptomyces, even though peculiar tRNA-based regulatory mechanisms operate in this… read more here.
Keywords: trna modifications; transcriptional trna; trna; albidoflavus j1074 ... See more keywords
Unveiling transfer RNA modifications of oil palm and their dynamic changes during fruit ripening
Sign Up to like & getrecommendations! Published in 2025 at "BMC Plant Biology"
DOI: 10.1186/s12870-025-06426-9
Abstract: The oil palm (Elaeis guineensis) is a crucial agricultural commodity, yielding the highest oil output among oil-bearing crops. Despite its significance, productivity challenges persist due to genetic and environmental factors. This study breaks new ground… read more here.
Keywords: modifications oil; fruit ripening; oil palm; dynamic changes ... See more keywords
Mitochondrial tRNA modifications: functions, diseases caused by their loss, and treatment strategies
Sign Up to like & getrecommendations! Published in 2024 at "RNA"
DOI: 10.1261/rna.080257.124
Abstract: Mitochondrial tRNA (mt-tRNA) modifications play pivotal roles in decoding and sustaining tRNA stability, thereby enabling the synthesis of essential respiratory complex proteins in mitochondria. Consequently, loss of human mt-tRNA modifications caused by mutations in the… read more here.
Keywords: caused loss; trna modifications; diseases caused; mitochondrial trna ... See more keywords
The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011937
Abstract: Transfer RNAs (tRNAs) are central to protein synthesis, ensuring precise decoding of the genetic code by delivering aminoacids to the ribosome. Among all RNA species, tRNAs are the most heavily and diversely modified, with modifications… read more here.
Keywords: biology; cholerae; vibrio cholerae; trna modifications ... See more keywords
Identification of the enzymes responsible for m2,2G and acp3U formation on cytosolic tRNA from insects and plants
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DOI: 10.1371/journal.pone.0242737
Abstract: Posttranscriptional modification of tRNA is critical for efficient protein translation and proper cell growth, and defects in tRNA modifications are often associated with human disease. Although most of the enzymes required for eukaryotic tRNA modifications… read more here.
Keywords: cytosolic trna; insects; trna modifications; formation cytosolic ... See more keywords
Variation of tRNA modifications with and without intron dependency
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2024.1460902
Abstract: tRNAs have recently gained attention for their novel regulatory roles in translation and for their diverse functions beyond translation. One of the most remarkable aspects of tRNA biogenesis is the incorporation of various chemical modifications,… read more here.
Keywords: variation trna; trna; modifications without; intron ... See more keywords
Making Sense of “Nonsense” and More: Challenges and Opportunities in the Genetic Code Expansion, in the World of tRNA Modifications
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020938
Abstract: The evolutional development of the RNA translation process that leads to protein synthesis based on naturally occurring amino acids has its continuation via synthetic biology, the so-called rational bioengineering. Genetic code expansion (GCE) explores beyond… read more here.
Keywords: code expansion; genetic code; biology; trna modifications ... See more keywords