Probing the diversity and regulation of tRNA modifications.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2020.06.005
Abstract: Transfer RNAs (tRNAs) are non-coding RNAs essential for protein synthesis. tRNAs are heavily decorated with a variety of post-transcriptional modifications (tRNA modifications). Recent methodological advances provide new tools for rapid profiling of tRNA modifications and… read more here.
Keywords: trna modifications; chemistry; diversity regulation; regulation trna ... See more keywords
Complete chemical structures of human mitochondrial tRNAs
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DOI: 10.1038/s41467-020-18068-6
Abstract: Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two species of mitochondrial (mt-)tRNAs encoded in mtDNA translate essential subunits of the respiratory chain complexes. mt-tRNAs contain post-transcriptional modifications introduced by nuclear-encoded tRNA-modifying enzymes. They are… read more here.
Keywords: mitochondrial trnas; human mitochondrial; trna modifications; chemical structures ... See more keywords
Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31158-2
Abstract: Transfer RNA (tRNA) from all domains of life contains multiple modified nucleosides, the functions of which remain incompletely understood. Genetic interactions between tRNA modification genes in Saccharomyces cerevisiae suggest that different tRNA modifications collaborate to… read more here.
Keywords: trna modifications; factor eef1a; trna; elongation factor ... See more keywords
Landscape of Post-Transcriptional tRNA Modifications in Streptomyces albidoflavus J1074 as Portrayed by Mass Spectrometry and Genomic Data Mining
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00294-22
Abstract: Post-transcriptional tRNA modifications (PTTMs) play an important role in maturation and functionality of tRNAs. Little is known about tRNA modifications in the antibiotic-producing actinobacterial genus Streptomyces, even though peculiar tRNA-based regulatory mechanisms operate in this… read more here.
Keywords: trna modifications; transcriptional trna; trna; albidoflavus j1074 ... See more keywords
Identification of the enzymes responsible for m2,2G and acp3U formation on cytosolic tRNA from insects and plants
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DOI: 10.1371/journal.pone.0242737
Abstract: Posttranscriptional modification of tRNA is critical for efficient protein translation and proper cell growth, and defects in tRNA modifications are often associated with human disease. Although most of the enzymes required for eukaryotic tRNA modifications… read more here.
Keywords: cytosolic trna; insects; trna modifications; formation cytosolic ... See more keywords
Making Sense of “Nonsense” and More: Challenges and Opportunities in the Genetic Code Expansion, in the World of tRNA Modifications
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020938
Abstract: The evolutional development of the RNA translation process that leads to protein synthesis based on naturally occurring amino acids has its continuation via synthetic biology, the so-called rational bioengineering. Genetic code expansion (GCE) explores beyond… read more here.
Keywords: code expansion; genetic code; biology; trna modifications ... See more keywords
tRNA Modifications and Modifying Enzymes in Disease, the Potential Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.80233
Abstract: tRNA is one of the most conserved and abundant RNA species, which plays a key role during protein translation. tRNA molecules are post-transcriptionally modified by tRNA modifying enzymes. Since high-throughput sequencing technology has developed rapidly,… read more here.
Keywords: trna modifications; disease potential; enzymes disease; modifying enzymes ... See more keywords